PMID: 8952959Jan 1, 1996Paper

Sequence and transcription of Qa-2-encoding genes in mouse lymphocytes and blastocysts

Immunogenetics
W CaiC M Warner

Abstract

The protein product of the mouse preimplantation embryo development (Ped) gene, which controls the rate of preimplantation embryonic cleavage division and subsequent embryo survival, is the Qa-2 antigen. This major histocompatibility complex (MHC) class I b protein is encoded by four genes, Q6, Q7, Q8, and Q9. The present study was undertaken to begin to elucidate which of the four Qa-2-encoding genes are responsible for the Ped gene phenotype in the C57BL/6 mouse (H2(b)). First, restriction maps of the four genes, using 25 restriction enzymes, were created. The RE maps confirmed that Q6 is similar to Q8 and Q7 is similar to Q9, but that the Q6/Q8 gene pair differs from the Q7/Q9 gene pair. The genomic DNA sequences of Q6 and Q8 were determined, as well as the DNA sequences of exons 4 - 8 of Q9, and the 5' regulatory regions of Q6, Q8, and Q9. This DNA sequence information, combined with the published DNA sequence information for the entire Q7 gene and exons 1 - 3 of Q9, allowed us to design primers for reverse transcription-polymerase chain reaction that could distinguish which of the four genes were transcribed in mouse lymphocytes and embryos. It was found that all four genes are transcribed in lymphocytes, but only Q7 and Q...Continue Reading

Citations

Sep 2, 1998·The Journal of Experimental Zoology·C M WarnerC Tang
Jul 13, 2002·The Journal of Experimental Zoology·Judith A NewmarkCarol M Warner
Mar 19, 2008·Journal of Assisted Reproduction and Genetics·Michael J Byrne, Carol M Warner
Mar 9, 2000·Journal of Reproductive Immunology·X Ke, C M Warner
Jun 11, 2008·The Journal of Experimental Medicine·Phillip A SwansonAron E Lukacher
Dec 28, 1999·Transplantation·J Y NiederkornI Stroynowski
Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·J C CooperG B Dealtry
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·T J Gill
Nov 5, 2005·The Journal of Physiology·Adam WatkinsTom P Fleming
Sep 25, 1998·Biology of Reproduction·L WuC M Warner
Jun 22, 2018·Molecular Brain·Dale B BoscoLong-Jun Wu
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula A Guidry, Iwona Stroynowski
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Phillip A SwansonAron E Lukacher
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene Y ChiangIwona Stroynowski
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene Y Chiang, Iwona Stroynowski
Feb 6, 2021·The Journal of Investigative Dermatology·Jianghong ZhongRikard Holmdahl

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