Sequence-Dependent Peptide Surface Functionalization of Metal-Organic Frameworks

ACS Applied Materials & Interfaces
Gang FanBenjamin K Keitz

Abstract

We report a noncovalent surface functionalization technique for water-stable metal-organic frameworks using short peptide sequences identified via phage display. Specific frameworks-binding peptides were identified for crystalline Zn(MeIM)2 (MeIM: 2-methylimidazole, ZIF-8), semiamorphous Fe-BTC (BTC: 1,3,5-benzene-tricarboxylate), and Al(OH)(C4H2O4) (MIL-53(Al)-FA, FA: fumaric acid), and their thermodynamic binding affinities and specificities were measured. Electron microscopy, powder X-ray diffraction, and gas adsorption analysis confirmed that the peptide-functionalized frameworks retained similar characteristics compared to their as-synthesized counterparts. Confocal laser-scanning microscopy demonstrated that peptide was localized on the surface of the frameworks, whereas surface area measurements showed no evidence of pore blockage. Finally, we measured the pH-dependent release of fluorescein from peptide-functionalized frameworks and discovered that peptide binding can attenuate fluorescein release by improving framework stability under low pH conditions. Our results demonstrate that phage display can be used as a general method to identify specific peptide sequences with strong binding affinity to water-stable metal-org...Continue Reading

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Citations

May 31, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Ross S Forgan
Jun 9, 2020·Frontiers in Chemistry·Asim Ali YaqoobMohamad Nasir Mohamad Ibrahim
Nov 26, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhonghui ChenZhenguo Chi
Feb 9, 2021·ACS Omega·Yuhao MaLarry D Unsworth
Feb 18, 2021·Chembiochem : a European Journal of Chemical Biology·Gang FanAriel L Furst
Jun 12, 2021·Frontiers in Chemistry·Mukesh MeenaPriyankaraj Sonigra
Sep 30, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Daohui ZhaoJian Zhou

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