Abstract
Sequence homology was searched among the nine cDNAs/deduced amino acid sequences encoding for the eight fertilization-related sperm antigens: namely, lactate dehydrogenase (LDH-C4), galactosyltransferase (GT), SP-10, rabbit sperm autoantigen (RSA), guinea pig (g)PH-20, cleavage signal protein (CS-1), HSA-63, human (h)PH-20, and AgX-1, respectively. Most significant identity (> 50%) was found between HSA-63 and SP-10 (59.8%), and between gPH-20 and hPH-20 (61.1%); followed by identity between SP-10 and GT (34.7%); and then between AgX-1 and hPH-20 (39.4%). All others had identity < 25%. The significance of these sequence homologies among the sperm antigens in the development of an antisperm contraceptive vaccine is discussed.
References
Mar 15, 1992·Gene·A A Javed, R K Naz
May 1, 1992·Biology of Reproduction·M S LiuC Y Lee
Apr 1, 1990·Biology of Reproduction·R M WrightJ C Herr
Jul 1, 1990·Human Reproduction·R Naz, A Menge
Oct 1, 1990·Biology of Reproduction·J E WelchM G O'Rand
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J L MillanE Goldberg
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R K NazB B Rosenblum
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R K NazA C Menge
Jul 20, 1984·Science·R K NazM S Hamilton
May 1, 1994·Biology of Reproduction·A B Diekman, E Goldberg
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y LinP Primakoff
Dec 1, 1993·Biology of Reproduction·R K NazP Martinez
Aug 1, 1959·American Journal of Obstetrics and Gynecology·S KATSH
Jul 4, 1964·Nature·R G EDWARDS
Jul 1, 1965·The Journal of Clinical Endocrinology and Metabolism·R E MANCINIM NEMIROVSKY
Citations
Sep 13, 2002·Expert Opinion on Investigational Drugs·Peter J Delves
Mar 12, 2004·Reproductive Biology and Endocrinology : RB&E·Anil Suri
Sep 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher M HardyKaren J Mobbs
Apr 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·W R Jones