PMID: 7529488Sep 1, 1994Paper

Sequence homology among sperm antigens involved in mammalian fertilization: search for a common epitope for immunocontraception

Archives of Andrology
X Zhu, R K Naz

Abstract

Sequence homology was searched among the nine cDNAs/deduced amino acid sequences encoding for the eight fertilization-related sperm antigens: namely, lactate dehydrogenase (LDH-C4), galactosyltransferase (GT), SP-10, rabbit sperm autoantigen (RSA), guinea pig (g)PH-20, cleavage signal protein (CS-1), HSA-63, human (h)PH-20, and AgX-1, respectively. Most significant identity (> 50%) was found between HSA-63 and SP-10 (59.8%), and between gPH-20 and hPH-20 (61.1%); followed by identity between SP-10 and GT (34.7%); and then between AgX-1 and hPH-20 (39.4%). All others had identity < 25%. The significance of these sequence homologies among the sperm antigens in the development of an antisperm contraceptive vaccine is discussed.

References

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Citations

Sep 13, 2002·Expert Opinion on Investigational Drugs·Peter J Delves
Mar 12, 2004·Reproductive Biology and Endocrinology : RB&E·Anil Suri
Sep 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher M HardyKaren J Mobbs
Apr 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·W R Jones

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