PMID: 6167988Jun 1, 1981Paper

Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin

Proceedings of the National Academy of Sciences of the United States of America
L L JagodzinskiJ Bonner

Abstract

We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat alpha a-fetoprotein mRNA. The resultant nucleotide sequence of alpha-fetoprotein was exhaustively compared to the nucleotide sequence of the mRNA encoding rat serum albumin. These two mRNAs have extensive homology (50%) throughout and the same intron locations. The amino acid sequence of rat alpha-fetoprotein has been deduced from the nucleotide sequence, and its comparison to rat serum albumin's amino acid sequence reveals a 34% homology. The regularly spaced positions of the cysteines found in serum albumin are conserved in rat alpha-fetoprotein, indicating that these two proteins may have a similar secondary folding structure. These homologies indicate that alpha-fetoprotein and serum albumin were derived by duplication of a common ancestral gene and constitute a gene family.

References

Feb 1, 1975·Acta Medica Okayama·A WatanabeK Kosaka
Apr 29, 1976·Nature·E Ruoslahti, W D Terry
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R HiguchiW Salser
Jul 14, 1978·Biochemical and Biophysical Research Communications·E H PetersT Tamaoki
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A LederP Leder
Mar 1, 1978·FEBS Letters·F Sanger, A R Coulson
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M Grunstein, D S Hogness
Mar 15, 1974·International Journal of Cancer. Journal International Du Cancer·H Watabe
Jun 28, 1969·Nature·R Van Furth, M Adinolfi
Mar 15, 1971·International Journal of Cancer. Journal International Du Cancer·E Ruoslahti, M Seppälä
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M B Gorin, S M Tilghman
Jan 11, 1980·Nucleic Acids Research·C BenoistP Chambon
Oct 1, 1980·Cell·A EfstratiadisN J Proudfoot
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T D SargentJ Bonner
Jun 1, 1980·Cell·F PerlerJ Dodgson

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Citations

Apr 1, 1991·Electrophoresis·A Ehara, S Nishi
Feb 1, 1992·Protein Science : a Publication of the Protein Society·J E Gray, R F Doolittle
Jan 1, 1984·Molecular & General Genetics : MGG·A GalJ M Sala-Trepat
Jan 1, 1984·The International Journal of Biochemistry·P StropF Mikes
Jan 1, 1990·Life Sciences·R YamamotoT Tamaoki
Jan 1, 1983·Advances in Enzyme Regulation·L BelangerJ M Boucher
Nov 22, 1994·Biochimica Et Biophysica Acta·C L Deng, L E Cornett
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Awad-Elkarim, G E Means
Jul 1, 1982·Gene·J W Hawkins, A Dugaiczyk
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B Bois-JoyeuxJ L Danan
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TeraiS S Thorgeirsson
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A DugaiczykO E Dennison
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S M Tilghman, A Belayew
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T MorinagaT Tamaoki
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J L NahonJ M Sala-Trepat
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J K ReddyN D Lalwani
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Nishio, A Dugaiczyk
Sep 11, 1984·Nucleic Acids Research·L Muglia, J Locker
Jan 11, 1985·Nucleic Acids Research·L Kunnath, J Locker
Mar 25, 1988·Nucleic Acids Research·K J Abel, K W Gross
Nov 25, 1981·Nucleic Acids Research·R M LawnK L Wion
Dec 19, 2000·Biochemical and Biophysical Research Communications·S H OhM Namba
Sep 1, 1991·Mutation Research·L Ho, P C Hanawalt

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