Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants

D FuT M Dunn


We have isolated, sequenced, mapped and disrupted a novel gene, CCC1, from Saccharomyces cerevisiae. This gene displays non-allelic complementation of the Ca(2+)-sensitive phenotype conferred by the csg1 mutation. The ability of this gene, in two copies per cell, to reverse the csg1 defect suggests it may have a role in regulating Ca2+ homeostasis. The sequence of CCC1 indicates that it encodes a 322 amino acid, membrane-associated protein. The CCC1 gene is located on the right arm of chromosome XII.


May 1, 1990·Molecular and Cellular Biology·T M Dunn, D Shortle
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·C T Caskey
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M V OlsonT Frank
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Jan 1, 1983·Methods in Enzymology·R J Rothstein
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Nov 1, 1986·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·R P Kaushik, K D Sharma

❮ Previous
Next ❯


Nov 4, 2011·Biochemistry·Allison L CockrellPaul A Lindahl
Aug 27, 2009·Chemical Reviews·Amit R ReddiValeria C Culotta
Feb 20, 2007·Applied and Environmental Microbiology·Eric HüfnerChristian Hertel
Aug 26, 1998·Annual Review of Nutrition·D J Eide
Aug 1, 1996·Molecular Microbiology·P J LapinskasV C Culotta
Jan 21, 2016·Nature Communications·Ksenija SlavicMaria M Mota
Apr 1, 1997·Folia Microbiologica·M SimkovicL Varecka
Jun 8, 2001·The Journal of Biological Chemistry·L LiJ Kaplan
Aug 8, 2007·The Journal of Biological Chemistry·Arvinder SinghDaniel J Kosman
Sep 19, 2019·Metallomics : Integrated Biometal Science·Paul A Lindahl

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.