PMID: 8964185Feb 1, 1996Paper

Sequence of alterations in subcellular organelles during the development of heart dysfunction in diabetes

Diabetes Research and Clinical Practice
N TakedaN S Dhalla

Abstract

Although changes in different subcellular organelles such as myofibrils, sarcoplasmic reticulum (SR), mitochondria and sarcolemma (SL), as well as in heart function have been reported to occur in chronic diabetes, their inter-relationships and functional significance are poorly understood. In order to gain information on this aspect, diabetes in rats was induced by an intravenous injection of streptozotocin and animals were assessed hemodynamically at 15-27 days. Ventricular tissue from several diabetic animals was pooled, subcellular organelles were isolated and their biochemical activities determined. Significant depressions in cardiac contractile and relaxation were observed to be associated with decreases in myofibrillar Ca(2+)-stimulated ATPase and SR Ca(2+)-pump activities at 21 days from the induction of diabetes. Likewise, the SL Na+-Ca2+ exchange and Ca(2+)-channel density were decreased at 21 days but the affinity of SL Ca(2+)-channels was increased in the diabetic heart. The SL Ca(2+)-pump and Na+-K+ ATPase activities were depressed at 18 and 24 days, respectively. Both alpha- and beta- adrenoceptor densities in SL were decreased at 27 days whereas no changes in mitochondrial function were observed at these early sta...Continue Reading

References

Jan 1, 1991·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·I NaganoN Noda
Dec 1, 1986·Circulation Research·P K GangulyN S Dhalla
Mar 1, 1981·Journal of Molecular and Cellular Cardiology·S PenpargkulJ Scheuer
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Citations

Feb 26, 2013·Heart Failure Reviews·Naranjan S DhallaVijayan Elimban
Apr 28, 2009·Journal of Diabetes and Its Complications·Frank Christopher HowarthMilos Ljubisavljevic
Apr 7, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Aled W RobertsKlaus K Witte
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Tom L BroderickMelissa Gillis
Feb 8, 2006·Canadian Journal of Physiology and Pharmacology·Jarmila MachackovaNaranjan S Dhalla
Dec 8, 2006·Annals of the New York Academy of Sciences·Xueliang LiuNaranjan S Dhalla
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Keshore R BidaseeU Deniz Dincer
Apr 5, 2020·International Journal of Molecular Sciences·Naranjan S DhallaParamjit S Tappia
Jun 1, 2018·Journal of Diabetes Research·L Al KuryF C Howarth
Oct 29, 2020·Journal of Diabetes Investigation·Lina T Al KuryFrank Christopher Howarth
Dec 2, 2020·Cells·Betul R ErdoganEbru Arioglu-Inan

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