PMID: 3383702Jan 1, 1988Paper

Sequence of centromere separation: differential replication of pericentric heterochromatin in multicentric chromosomes

Chromosoma
B K Vig, D Broccoli

Abstract

The dicentric and multicentric chromosomes in L cells and a brain tumor cell line of mouse display only one site of kinetochore formation associated with the 'active' centromere. The accessory or 'inactive' centromeres show premature separation. These cell lines were treated with 10(-6) M 5-bromodeoxyuridine (BrdUrd) followed by anti-BrdUrd antibody to study the pattern of replication of pericentric heterochromatin flanking the active vs inactive centromeres. Regardless of its quantity, heterochromatin around the inactive centromere replicates earlier than that associated with the active centromere. There appears to be a relationship between the timing of separation of a centromere and the timing of replication of pericentric heterochromatin. The premature replication of heterochromatin associated with an inactive centromere may be responsible for its premature separation and, hence, inactivity.

References

Jan 1, 1977·Cytogenetics and Cell Genetics·Y F Lau, T C Hsu
Oct 1, 1986·The Journal of Cell Biology·L M LicaB A Hamkalo
Jan 1, 1986·Chromosoma·R P ZinkowskiD Broccoli
Aug 1, 1986·Cancer Genetics and Cytogenetics·B K Vig, R P Zinkowski
Jan 1, 1985·Chromosoma·J B Rattner, C C Lin
Feb 11, 1981·Nucleic Acids Research·W Hörz, W Altenburger
Mar 1, 1983·Cancer Genetics and Cytogenetics·B K Vig
Aug 1, 1984·Mutation Research·B K VigD S Michaelson

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Citations

Oct 19, 2005·Histochemistry and Cell Biology·Stefanie Weidtkamp-PetersPeter Hemmerich
Aug 1, 1994·Mutation Research·B K Vig
Oct 1, 1989·Cancer Genetics and Cytogenetics·N PaweletzE M Finze
Dec 1, 1989·Cancer Genetics and Cytogenetics·B K VigN Paweletz
Nov 1, 1990·Cancer Genetics and Cytogenetics·B K VigN Paweletz
Jul 29, 2000·Cancer Genetics and Cytogenetics·A Garcia-OradD Aucoin
Sep 2, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lada ZivkovićVladan Bajić

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