PMID: 3383699Jan 1, 1988Paper

Sequence of centromere separation: generation of unstable multicentric chromosomes in a rat cell line

Chromosoma
B K Vig, N Paweletz

Abstract

A transformed cell line, B1, of cerebral endothelial origin from the Wistar-Kyoto male rat has chromatid and chromosome type bridges in virtually every cell. It exhibits various dicentric and polycentric chromosomes. Most dicentrics are symmetric isochromosomes. Certain isodicentrics are present in a fair segment of the cell population; however, almost all cells have some newly arising isodicentrics. The live cells show a lengthened prometaphase. Anaphase is also retarded possibly due to the occurrence of bridges. At anaphase some multicentrics split at only one centromere. When pulled to the two poles the unsplit centromeres and the distal chromosome segment form a side arm bridge. Another mechanism appears to be a total lack of separation of daughter centromeres at meta-anaphase ('meiotic-like' behavior of mitotic chromosomes). This is realized by the pulling of each of the two unsplit centromeres to opposite poles and results in bridges with both sister chromatids running parallel to each other. A break at corresponding weak points in the two sister chromatids followed by rejoining can form a dicentric isochromosome. A third mechanism, the breakage-fusion-bridge cycle, is also operative but would not produce isodicentrics. I...Continue Reading

References

Jan 1, 1986·Chromosoma·R P ZinkowskiD Broccoli
Oct 1, 1987·Cancer Genetics and Cytogenetics·G KovacsS Szücs
Aug 1, 1986·Cancer Genetics and Cytogenetics·B K Vig, R P Zinkowski
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Jul 1, 1983·The Journal of Cell Biology·C A DiglioP Meyers
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·M TyrkusN Gohle
Aug 1, 1980·The Journal of Cell Biology·P K Hepler

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Citations

Oct 1, 1989·Cancer Genetics and Cytogenetics·N PaweletzE M Finze
Dec 1, 1989·Cancer Genetics and Cytogenetics·B K VigN Paweletz
Nov 1, 1990·Cancer Genetics and Cytogenetics·B K VigN Paweletz
Jan 1, 1995·Cancer Genetics and Cytogenetics·K L Sternes, B K Vig

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