Sequence of events in substance P-mediated plasma extravasation in rat skin.

Brain Research
Z Khalil, R D Helme

Abstract

Using a blister model of inflammation in the rat hind footpad, we have studied the temporal and quantitative contribution of mast cell mediators and prostaglandins to substance P-induced plasma extravasation. In addition substance P-related peptides (neurokinin A, SP5-11 and SP1-7) were tested for their ability to induce a plasma extravasation response and the extent of histamine involvement to the response was determined. The present results show that the plasma extravasation response to substance P consists of an early substance P-mediated response that is independent of other mediators and a late response that involves interaction between substance P, mast cell mediators and prostaglandins. An early histamine-independent response was also mediated by neurokinin A, a tachykinin that shares a common C-terminal with substance P and by a C-terminally directed analogue of substance P, namely SP5-11. On the other hand, a late histamine-dependent response was mediated by the N-terminally directed analogue, SP1-7. The present data are suggestive of a possible sequence of events that might occur during an inflammatory response to substance P and might involve independent actions of its C- and N-terminal.

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Citations

Aug 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M BassiratZ Khalil
Nov 20, 1989·Neuroscience Letters·N M O'FlynnE Burcher
Sep 30, 1999·Peptides·R V AlvesJ B Calixto
May 1, 1993·The Journal of Experimental Medicine·E W GreenoC F Moldow
Aug 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L J PetersenP S Skov
Oct 11, 2005·Neuro-Signals·Louis Vera-Portocarrero, Karin N Westlund
Sep 16, 2000·Archives of Histology and Cytology·A Hiura
Sep 18, 2004·The Journal of Investigative Dermatology·Zeinab KhalilPrue H Hart
Dec 18, 2002·The Journal of Investigative Dermatology·MarcosA AntezanaJohnE Olerud
Nov 26, 2008·Journal of Diabetes and Its Complications·Maryam Bassirat, Zeinab Khalil
Aug 1, 1989·British Journal of Pharmacology·P V AndrewsK L Thomas
Sep 19, 2006·Toxicon : Official Journal of the International Society on Toxinology·Bruce G LivettZeinab Khalil
Apr 4, 1994·Brain Research·Z KhalilR D Helme
May 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·C M KählerC J Wiedermann
May 20, 2006·Journal of Neurophysiology·Sandra Valencia-de ItaWilliam D Willis

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