Sequence of refusals for donor quality, organ utilization, and survival after lung transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Eshita SinghFarhan Zafar

Abstract

Lung donor utilization rates remain low, with many organs refused for donor quality. However, some centers have successfully transplanted these organs despite multiple refusals for donor quality (RDQs) by other centers. We hypothesized that the number of refusals due to donor quality does not impact post-transplant outcomes. Lung transplants (LTxs) from 2006 to 2015, identified using the United Network for Organ Sharing (UNOS) database, were matched against the potential transplant recipient (PTR) data set by donor identification. Transplants were categorized into 2 groups: low RDQ (0 to 3 RDQs) and high RDQ (>3 RDQs). Post-transplant survival and predictors for high RDQ were observed using Kaplan‒Meier and logistic regression analyses, respectively. Of 10,126 adult (>18 years) LTxs, 77% had at least 1 RDQ, with a median of 4 RDQs. Post-transplant 1-year survival was similar for both the low and high RDQ groups (p = 0.49). Furthermore, groups of recipients who received donors with an increasing number of RDQs (>3, >6, or >10) also had similar post-transplant 1-year survival (p = 0.77). Treatment for rejection within 1 year and intubation at 72 hours post-transplant were higher in the high RDQ group (p < 0.01). An inverse relati...Continue Reading

Citations

Mar 2, 2019·Annals of the American Thoracic Society·Luke J Benvenuto, Meghan Aversa
Nov 16, 2019·Journal of Cardiac Surgery·Andrea L AxtellMauricio A Villavicencio
Dec 6, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Fariba GhorbaniMeysam Mojtabaee
Oct 31, 2020·The Annals of Thoracic Surgery·Shuji OkaharaGregory I Snell
Jul 7, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sapna S HumarSusan Abbey

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