PMID: 3753882Feb 24, 1986Paper

Sequence of the cDNA encoding porcine pro-opiomelanocortin

Biochimica Et Biophysica Acta
F J GossardS N Cohen

Abstract

Messenger RNA was extracted from porcine pituitary pars intermedia and cloned as cDNA by standard methods. The nucleotide sequence encoding porcine pro-opiomelanocortin was established from analysis of two separate cDNA segments having an overlap of 420 bases. The amino acid sequence for the porcine pro-opiomelanocortin protein, which was inferred from the cDNA sequence, was found to correspond exactly to the sequence determined by direct amino acid analysis of the component peptides of pro-opiomelanocortin; namely, the porcine hormones ACTH, beta-lipotropin, gamma-MSH and the connecting peptide. We thus find no evidence for the existence of two porcine pro-opiomelanocortin genes that differ in their coding sequences, as was suggested by the in vitro protein synthesis results of others using mRNA obtained from porcine pituitaries.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J L Roberts, E Herbert
Sep 1, 1979·Canadian Journal of Biochemistry·M ChrétienN G Seidah
May 14, 1969·Journal of Molecular Biology·H W Boyer, D Roulland-Dussoix
Jun 13, 1966·Biochemical and Biophysical Research Communications·D T Denhardt
Aug 1, 1966·Canadian Journal of Microbiology·D H Evans
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jun 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·G BoileauM Chrétien
Jan 1, 1980·Methods in Enzymology·A M Maxam, W Gilbert
Apr 1, 1981·European Journal of Biochemistry·S NakanishiS Numa
Nov 1, 1981·International Journal of Peptide and Protein Research·N LarivièreM Chrétien
Jan 29, 2008·The Journal of Biological Chemistry·Kuo-Kuang WenPeter A Rubenstein

❮ Previous
Next ❯

Citations

Aug 31, 1987·Neuroscience Letters·F GossardG Morel
May 24, 2003·Brain Research. Developmental Brain Research·Hélène TollemerHubert Vaudry
Oct 1, 1996·The American Journal of Physiology·J MurotsukiJ R Challis
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N KitaharaG I Soma
Dec 1, 1989·Archives of Biochemistry and Biophysics·R B Harris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.