PMID: 418775May 1, 1978Paper

Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11

The Biochemical Journal
G P Smith


MPC 11 mouse myeloma cells synthesize two immunoglobulin kappa light chains, coded by two separate genes. One of these Kappa-chains has no variable region and is degraded intracellularly. The other is a full-length kappa-chain contaning both variable and constant regions: this chain is secreted, both by itself and combined with heavy chains in molecules of immunoglobulin G. This paper reports the amino acid sequence of the myeloma MPC 11 full-length kappa-chain. The chain is unusual in having 12 extra residues at its N-terminus when its sequence is aligned with those of other mouse kappa-chains; no other anomalies were found in its sequence.


Jan 1, 1979·Journal of Supramolecular Structure·L W Bergman, W M Kuehl
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeff X ZhouHerbert C Morse
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Betul GulogluChristopher A J Roman

Related Concepts

Framework Region, Immunoglobulin
Kappa-Immunoglobulin Subgroup VK-21
Immunoglobulin Light Chains
Multiple Myeloma

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