PMID: 7545974Oct 1, 1994Paper

Sequence organization of the human chromosome 2q telomere

Human Molecular Genetics
R A MacinaH C Riethman

Abstract

The terminal 240 kb of a human 2q telomere region was cloned in two overlapping yeast artificial-chromosomes (YACs). This DNA contains a region of low-copy subtelomeric repeats (within 50 kb of the 2q telomere), a segment of DNA duplicated on distal 8p23 (100 kb from the 2q telomere), and a region of single-copy DNA (230 kb from the 2q telomere). Two CpG islands are present in the DNA segment duplicated on distal 8p23. RecA-assisted restriction endonuclease cleavage of genomic DNA samples revealed a potential 55 kb chromosome length polymorphism at the 2q telomere. This work provides telomeric closure of maps for human chromosome 2q, demonstrates a novel, subtelomere-specific DNA duplication, and will permit detailed molecular and cytological studies of this human telomere region.

Citations

Sep 1, 2005·Indian Journal of Pediatrics·Gopalrao V N VelagaletiLillian H Lockhart
Sep 1, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·H RiethmanS Paul
Mar 1, 1995·Genomics·J T RestonH C Riethman
Feb 1, 1997·Current Opinion in Biotechnology·W Szybalski
Jul 27, 2001·Nucleic Acids Research·J A Londoño-VallejoG Thomas
Nov 21, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Y S FanV M Siu
Feb 13, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Daynna J WolffJane Charles
Apr 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Andrew WongDavid H Ledbetter
Jan 7, 2004·Genome Research·Harold RiethmanJun Wei
Nov 8, 2002·Genome Research·Hera Der-SarkissianJosé-Arturo Londoño-Vallejo
Oct 4, 2002·Journal of Medical Genetics·C L MartinD H Ledbetter
Jan 1, 2008·Cytogenetic and Genome Research·H Riethman
Aug 1, 2007·Genome Biology·Anthony AmbrosiniHarold Riethman
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R OfirS Selig
Feb 13, 2002·American Journal of Medical Genetics·Britt-Marie AnderlidMagnus Nordenskjöld
Aug 28, 2010·American Journal of Medical Genetics. Part a·Ascensión Vera-CarbonellEncarna Guillén-Navarro
Sep 3, 2010·Journal of Intellectual Disability Research : JIDR·D M ChristofoliniM I Melaragno
Oct 7, 2004·American Journal of Human Genetics·Richard J F L LemmersSilvere M van der Maarel
Sep 24, 2004·American Journal of Medical Genetics. Part a·Kari A CasasRena E Falk
May 12, 2007·Human Mutation·Irina BalikovaJoris Robert Vermeesch
Oct 3, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·David H Ledbetter, Christa Lese Martin
Feb 12, 2002·Nature Reviews. Genetics·Heather C Mefford, Barbara J Trask
Jan 21, 2015·Current Protocols in Human Genetics·Christa Lese Martin, David H Ledbetter
Jan 28, 2020·PLoS Genetics·Eleanor YoungMing Xiao
Oct 6, 1997·Genome Research·H Riethman
Oct 6, 1997·Genome Research·M RosenbergJ Flint
Apr 23, 2008·Current Protocols in Human Genetics·C M Lese, D H Ledbetter
Aug 1, 2020·Comparative Cytogenetics·Magdalena AchremAnna Kalinka
Jan 29, 2019·Frontiers in Genetics·Haochang HuShiwei Duan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.