Sequence profiles of immunoglobulin and immunoglobulin-like domains

Journal of Molecular Biology
D K Smith, H Xue

Abstract

Immunoglobulins (Ig) are highly modular proteins, consisting of variable and constant domains, which have clear, conserved sequence patterns. These sequence patterns have allowed T-cell receptor (TCR) and major histocompatibility complex (MHC) molecule domains, as well as some cell adhesion, cell surface receptor and muscle protein domains, to be identified as forming a superfamily of related proteins together with the Ig-domains. The domains of these proteins have been grouped into four sets: variable (V-set), constant-1 (C1-set), constant-2 (C2-set) and intermediate (I-set). X-ray and NMR studies have shown that these domains form a Greek-key beta-sandwich structure with the sets differing in the number of strands in the beta-sheets as well as in their sequence patterns. The conserved sequence elements in the major sets of Ig and Ig-like molecules have previously been reported as general sequence profiles. This work examines the variability within these sets. Detailed sequence profiles and consensus sequences for these sets and groups have been constructed and a novel form of presentation has been developed to overcome some of the drawbacks of current methods of presenting consensus sequences. The profiles that were construct...Continue Reading

Citations

Jul 25, 2009·The Journal of Biological Chemistry·Deborah HatherleyA Neil Barclay
Sep 8, 2012·The Journal of Biological Chemistry·Kirsten B BojesenVladimir Berezin
Apr 6, 2000·Molecular Biology of the Cell·H M ChenM J Bissell
Jan 14, 2012·Protein Engineering, Design & Selection : PEDS·Steven A JacobsKaryn T O'Neil
Jul 27, 2000·Molecular and Cellular Biology·J C ArevaloP Perez
Apr 5, 2012·Journal of Clinical Bioinformatics·Khader Shameer, Ramanathan Sowdhamini
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jan Klein, Nikolas Nikolaidis
Jun 10, 1998·Journal of Molecular Biology·C ChothiaA Kister
Oct 24, 2006·Developmental Biology·Stefan C MaternaR Andrew Cameron
Oct 3, 2006·Developmental Biology·Anthony J RobertsonJames A Coffman
Aug 6, 1999·Protein Engineering·D M HalabyJ Mornon
Dec 10, 1999·Protein Engineering·B A GalitskyA E Kister
Dec 30, 1998·Archives of Pharmacal Research·J JungK Lee
Oct 1, 2005·Protein Science : a Publication of the Protein Society·Zhiwen XuHong Xue
Feb 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanbin FuYaofeng Zhao
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiao LiWei Xiong
May 29, 2001·The Journal of Biological Chemistry·K FurukawaH Nakamura
Oct 9, 2001·The Journal of Biological Chemistry·M P ArrateS A Cunningham
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N FournierP Garrone
Jan 1, 2010·Experimental and Therapeutic Medicine·Lei ZhuangBeat Trueb
Jul 17, 2015·The Journal of Biological Chemistry·Isi A Ero-TolliverGautam Bhave
Mar 9, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rong ChenChun Xia
Aug 24, 2017·Amino Acids·Svetlana TarnovskayaDmitrij Frishman
Jun 12, 2020·Scientific Reports·Kheerthana Duraivelan, Dibyendu Samanta
May 25, 1999·Progress in Neurobiology·R Probstmeier, P Pesheva
Mar 15, 2006·Cell·Karim Y HelmyMenno van Lookeren Campagne
Sep 13, 2017·Biochemistry·Marawan Ahmed, Khaled Barakat
Jul 1, 2008·Mechanisms of Development·Ozlem OralShin-Ichi Abé
Aug 5, 2008·Biochimica Et Biophysica Acta·Angela De IuliisFabio Vianello

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