PMID: 6405042Feb 15, 1983Paper

Sequence replication and banding organization in the polytene chromosomes of Drosophila melanogaster

Journal of Molecular Biology
E Lifschytz

Abstract

The relative proportions of cloned DNA fragments from all known hierarchies of sequence organization in polytene and diploid chromosomes were compared. It was found that unique sequences of varying sizes and chromosomal locations are equally replicated in salivary gland chromosomes. Sequences of euchromatic polydisperse gene families are also replicated proportionately in polytene and diploid tissues. Perhaps the most significant finding is that the histone gene repeats, despite their normal banding organization, are under-replicated in the polytene chromosome of Drosophila melanogaster. However, the clustered and well-banded 5S genes are most likely equally replicated. It is therefore concluded that differential sequence replication plays no apparent role in either the assembly or morphology of a band; and likewise, the assembly of polytenic DNA into band units is not affected by either the local abundancy or arrangement of middle repetitive sequences. The likelihood that the clustered arrangement is an important factor in the selection of sequences for under-replication is discussed.

References

Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·R P LiftonD S Hogness
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M W Young
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R J KaufmanR T Schimke
Dec 1, 1977·Cell·S Artavanis-TsakonasW J Gehring
Jul 1, 1978·Nucleic Acids Research·P J GreeneH W Boyer
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M Grunstein, D S Hogness
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B B Spear, J G Gall
Jan 1, 1971·Chromosoma·J G GallM L Polan
Nov 1, 1968·Chromosoma·H V Crouse, H G Keyl
Jan 1, 1980·Molecular & General Genetics : MGG·A I ChernyshevR B Khesin
Dec 1, 1980·Cell·C D Laird
Feb 1, 1980·Cell·E A FyrbergK L Kindle
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·V CorcesM Meselson
Jan 1, 1980·Annual Review of Genetics·D L Brutlag
Jan 1, 1981·Annual Review of Genetics·A C Spradling, G M Rubin
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L R Beach, R D Palmiter
Jul 10, 1964·Science·S W BROWN, U NUR

❮ Previous
Next ❯

Citations

Jan 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Miklos, J N Cotsell
Jan 1, 1985·Molecular & General Genetics : MGG·E Lifshytz, D Hareven
Sep 1, 1986·Developmental Biology·S ParksA Spradling
Jun 1, 1986·Studies in History and Philosophy of Science·R Falk
Jun 1, 1996·Genome Génome / Conseil National De Recherches Canada·E PardaliP Mavragani-Tsipidou
Aug 1, 1986·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Helmut Zacharias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.