Sequence-specific DNA modification in Neisseria gonorrhoeae.

Journal of Bacteriology
C KorchS Normark

Abstract

Neisseria gonorrhoeae 82409/55(pJD1) is postulated to possess six DNA sequence-specific cytosine methyltransferases and one DNA sequence-specific N6-adenine methyltransferase. From the DNA sequencing of the plasmid pJD1 (manuscript in preparation) by a modification of the Maxam and Gilbert chemical cleavage procedure, the cytosine methylation specificities were demonstrated. Five of these methylating enzymes and their respective specificities are M . NgoI (formula; see text) does not methylate the cytosine of its recognition sequence, in agreement with a detected adenine modification. A biological implication of these different DNA methylating activities is discussed.

References

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Citations

Feb 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·R B Aalen, W B Gundersen
Dec 29, 1998·Biological Chemistry·E LorbachP Dröge
May 19, 1995·Gene·D C SteinA Piekarowicz
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Apr 1, 1989·Clinical Microbiology Reviews·G D BiswasP F Sparling
Apr 1, 1989·Clinical Microbiology Reviews·J K Davies
May 1, 1985·Annales De L'Institut Pasteur. Microbiology·M F Prère, O Fayet

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