PMID: 2511555Nov 11, 1989Paper

Sequence, structure and evolution of the gene coding for sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster

Nucleic Acids Research
G C BewleyG K Chambers

Abstract

We present the complete nucleotide and deduced amino acid sequence for the gene encoding Drosophila sn-glycerol-3-phosphate dehydrogenase. A transcription unit of 5kb was identified which is composed of eight protein encoding exons. Three classes of transcripts were shown to differ only in the 3'-end and to code for three protein isoforms each with a different C-terminal amino acid sequence. Each transcript is shown to arise through the differential expression of three isotype-specific exons at the 3'-end of the gene by a developmentally regulated process of 3'-end formation and alternate splicing pathways of the pre-mRNA. In contrast, the 5'-end of the gene is simple in structure and each mRNA is transcribed from the same promoter sequence. A comparison of the organization of the Drosophila and murine genes and the primary amino acid sequence between a total of four species indicates that the GPDH gene-enzyme system is highly conserved and is evolving slowly.

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Citations

Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·T M WilanowskiJ E Symonds
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·F J AyalaJ Kwiatowski
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·F J Ayala
Jan 1, 1997·Journal of Molecular Evolution·J KwiatowskiF J Ayala
Apr 22, 1996·Proceedings. Biological Sciences·R S Wells

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