Sequence Symmetry Analysis as a Signal Detection Tool for Potential Heart Failure Adverse Events in an Administrative Claims Database

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Izyan A WahabElizabeth E Roughead

Abstract

The potential for routine sequence symmetry analysis (SSA) signal detection in health claims databases to detect new safety signals of medicines is unknown. Our objective was to assess the potential utility of SSA as a signal detection tool in health claims data for detecting medicines with potential heart failure (HF) adverse event signals. We applied the SSA method to all subsidized single-ingredient medicines in Australia. The source of data was the Australian Government Department of Veterans' Affairs (DVA) administrative claims database using data collected between 2002 and 2011. We used first ever HF hospitalization and frusemide initiation as indicators for HF. A signal was considered to be present if the lower limit of the 95 % confidence interval for the adjusted sequence ratio was greater than one. To identify potential new signals of HF, we excluded medicines where HF or edema was listed in the product information (PI) of that medicine or for any other medicine in the same class. We also excluded medicines that were used in HF treatment and medicines indicated for diseases that may contribute to the development of HF. We tested 691 medicines. HF signals were detected for 12 % (80/691) using the hospitalization event ...Continue Reading

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Citations

May 12, 2017·Expert Opinion on Drug Safety·Mickael ArnaudFrancesco Salvo
Feb 23, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ed WhalenAndrew Bate
Mar 3, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maja HellfritzschAnton Pottegård
Apr 2, 2018·European Journal of Epidemiology·Jesper HallasAnton Pottegård
Jan 1, 2019·Current Epidemiology Reports·Nicole Pratt, Elizabeth Roughead
Jun 25, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Clare E KingEirene C Behm
Jul 13, 2017·European Journal of Epidemiology·Edward Chia-Cheng LaiJesper Hallas
Aug 12, 2021·Research in Social & Administrative Pharmacy : RSAP·Earl J MorrisScott M Vouri

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