PMID: 8605246Feb 7, 1996Paper

Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter

Biochimica Et Biophysica Acta
K MiyamotoE Takeda

Abstract

Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. The cDNA sequence indicates that rat PepT1 is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepT1, respectively. Northern blot analysis detected rat PepT1 mRNA in the small intestine and kidney. Intestinal PepT1 mRNA levels were highest in 4-day old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development.

References

Mar 16, 1992·Biochemical and Biophysical Research Communications·K MiyamotoH Hagihira
Dec 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·M K YounoszaiM H Finch

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