PMID: 15223781Jun 30, 2004Paper

Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia

Investigative Ophthalmology & Visual Science
Genaro S ScavelloTerri L Young

Abstract

High myopia is a common complex-trait eye disorder, with implications for blindness due to increased risk of retinal detachment, macular degeneration, premature cataracts, and glaucoma. Mapping studies have identified at least four loci for nonsyndromic autosomal dominant high myopia at 18p11.31, 12q22-q23, 17q21-q23, and 7q36. The smallest haplotyped interval for these loci is that of the MYP2 locus on 18p11.31. Recently, the transforming growth beta-induced factor (TGIF) gene was reported to be a candidate gene for MYP2-associated high myopia in single-nucleotide polymorphism studies. The purpose of this study was to determine whether DNA sequence variants in the human TGIF gene are causally related to MYP2-associated high myopia. The protein coding regions and intron-exon boundaries of the human TGIF gene were sequenced using genomic DNA samples from MYP2 individuals (affected, unaffected) and external control subjects. The TGIF model used was the April 20, 2003, human genome National Center for Biotechnology Information (NCBI) build 33, which has 10 exons and encodes eight transcript variants. Polymorphic sequence changes were compared to those in the previous report. Reverse-transcription polymerase chain reaction (RT-PCR)...Continue Reading

Citations

Dec 24, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Terri L Young
Aug 1, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Rufino Silva
Nov 30, 2007·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Wing Chun TangShea Ping Yip
Sep 12, 2006·Molecular Genetics and Metabolism·Kenia B El-JaickMaximilian Muenke
Nov 13, 2013·Current Eye Research·Ishfaq AhmedKhurshid I Andrabi
Jan 18, 2006·Clinical Biochemistry·Bao Jian FanChi Pui Pang
Apr 8, 2020·Clinical Ophthalmology·Sangeethabalasri PugazhendhiAllan A Hunter

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