Sequence variants of peroxisome proliferator-activated receptor-gamma gene and the clinical courses of patients with end-stage renal disease

Disease Markers
Chia-Ter ChaoChung-Jen Yen

Abstract

PPAR-γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population. Whether PPAR-γ SNPs affect the clinical courses in ESRD patients is unknown. From a multicenter cohort, we identified 698 patients with prevalent ESRD between 2002 and 2003, and other 782 healthy subjects as control. Two PPAR-γ SNPs, Pro12Ala (rs1801282) and C161T (rs3856806), were genotyped and their association with ESRD was examined. Both groups were prospectively followed until 2007, and the predictability of genotypes for the long-term survival of ESRD patients was analyzed. After multivariable-adjusted regression, GG genotype of Pro12Ala was significantly more likely to associate with ESRD (P < 0.001) among patients with non-diabetes-related ESRD. Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001). This is the first and largest study to evaluate PPAR-γ SNPs in ESRD patients. Further mechanistic study is needed to eluci...Continue Reading

References

Nov 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefan MoellerGail Brown
Sep 10, 2004·The New England Journal of Medicine·Hannele Yki-Järvinen
Jan 5, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bhavani Prasad KotaBasil D Roufogalis
Feb 6, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI
Jul 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wu-Chang YangUNKNOWN Taiwan Society of Nephrology
Oct 18, 2008·Immunobiology·Attila Szanto, Laszlo Nagy
Feb 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S LeveyUNKNOWN Centers for Disease Control and Prevention Expert Panel
Aug 31, 2010·Current Opinion in Nephrology and Hypertension·Ron T GansevoortStephan J L Bakker
Oct 5, 2010·Endocrine Journal·Akira SugawaraSadayoshi Ito
Feb 18, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Nanping WangFang Xi
Mar 14, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jai PrakashBalraj Mittal
Jun 19, 2012·Trends in Endocrinology and Metabolism : TEM·Walter Wahli, Liliane Michalik
Sep 24, 2013·Genetic Testing and Molecular Biomarkers·Bin MaoFengling Zhuo
Nov 6, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesca Mallamaci, Giovanni Tripepi

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SAS

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