PMID: 3755748Sep 1, 1986Paper

Sequences and diversity of human T cell receptor beta chain variable region genes

The Journal of Experimental Medicine
N KimuraT W Mak

Abstract

The nucleotide sequences of 22 human T cell antigen receptor (TcR) beta chain variable region genes isolated from various T lymphocytes have been analyzed. Of the 19 variable gene segment (V beta)-containing sequences, 17 were unique. The V beta gene segments were grouped into 11 families. Comparisons were made with the data of Concannon et al. to unify the nomenclature. The data is consistent with a total V beta gene segment repertoire with a most probable value of 38 members and an upper bound of 104 members at the 95% confidence level. Southern blot data of germline DNA using selected TcR V beta cDNAs as probes support this estimate. The human repertoire is approximately three to four times greater than that reported for the mouse. Explanations for this discrepancy are proposed.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1986·Analytical Biochemistry·E C StraussL E Hood
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A BehlkeD Y Loh
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K IkutaT Honjo
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B ToyonagaT W Mak
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y YanagiT W Mak
Dec 20, 1984·Nature·G K SimJ Kappler

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Citations

Apr 1, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J van Dongen, I L Wolvers-Tettero
Aug 1, 1995·Immunology and Cell Biology·C Olive
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M H KleinL Hood
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y W ChoiJ Kappler
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R JoresT Meo
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R BaccalaA N Theofilopoulos
Apr 1, 1987·The Journal of Experimental Medicine·P ConcannonL E Hood
Dec 1, 1991·The Journal of Experimental Medicine·Y LiD N Posnett
May 1, 1994·The Journal of Experimental Medicine·J P DonahueB L Kotzin
May 1, 1994·The British Journal of Dermatology·P M McHenryR M Mackie
Aug 1, 1993·Scandinavian Journal of Immunology·J CihakH W Ziegler-Heitbrock
Oct 20, 1989·European Journal of Biochemistry·T Boehm, T H Rabbitts
Dec 30, 1991·Annals of the New York Academy of Sciences·D A HaflerH L Weiner
Jul 7, 1995·Annals of the New York Academy of Sciences·P Concannon, M A Robinson
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·D GestriL Massacesi

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