Sequences assessed by declarative and procedural tests of memory in amnesic patients with hippocampal damage

Neuropsychologia
Ramona O HopkinsRaymond P Kesner

Abstract

Previous research indicates that amnesic subjects tested on sequential learning or serial reaction time tasks can learn a repeated procedural sequence but are unable to explicitly recall the correct sequence when asked to generate the sequence. Rats with hippocampal lesions are also able to learn and remember procedural or implicit sequences but were impaired for declarative sequences. We used analogous procedures used in rats to assess the role of the hippocampus in the acquisition of declarative and procedural sequences in amnesic and control participants. Amnesic participants with damage restricted to the hippocampus and control participants were administered analogous tasks of declarative and procedural sequential learning using a computer version of the radial arm maze. The amnesic participants had slower response times during the acquisition of procedural sequences, but were not impaired compared to controls when switched to a random sequence, suggesting that both groups learned the sequence. Alternatively, the amnesic but not control participants were significantly impaired in the declarative sequence task. Our findings provide support for evolutionary continuity in cognitive function of the hippocampus in rats and human...Continue Reading

References

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Citations

May 27, 2010·Brain Imaging and Behavior·Mary R SuchytaRamona O Hopkins
Jul 29, 2009·Journal of the International Neuropsychological Society : JINS·Eva PirogovskyPaul E Gilbert
Nov 7, 2007·Neuropsychology·Cherie L MarvelNancy C Andreasen
Apr 19, 2007·PloS One·Spyridon DrosopoulosJan Born
Jul 9, 2005·Current Opinion in Neurology·Christian Forkstam, Karl Magnus Petersson
Aug 4, 2015·Neurotoxicity Research·Sebastian Busse, Rainer K W Schwarting
Feb 17, 2009·Hippocampus·Robert S RossChantal E Stern
Jun 26, 2009·Hippocampus·Naomi J Goodrich-HunsakerRamona O Hopkins
May 8, 2014·Hippocampus·Timothy A AllenNorbert J Fortin
May 9, 2014·Hippocampus·Jared M RobertsMichael A Yassa
Feb 14, 2006·Biological Psychology·Raymond P Kesner, Ramona O Hopkins
Nov 4, 2009·Neuropsychologia·Raymond P Kesner, Naomi J Goodrich-Hunsaker
Feb 16, 2006·Neuron·Dharshan Kumaran, Eleanor A Maguire
Jun 10, 2014·Neurobiology of Learning and Memory·Van RedilaSheri J Y Mizumori
Feb 6, 2015·Frontiers in Systems Neuroscience·Radhika MadhavanWilliam S Anderson
Mar 30, 2017·Brain Injury : [BI]·Kacie L WrightRamona O Hopkins

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