PMID: 2124350Dec 25, 1990Paper

Sequences of human immunoglobulin switch regions: implications for recombination and transcription

Nucleic Acids Research
F C MillsR D Camerini-Otero

Abstract

We have sequenced the entire human S mu and S gamma 4 immunoglobulin heavy chain class switch regions, and have also completed the sequence of human S epsilon. S mu is composed predominantly of GAGCT and GGGCT pentameric repeats, with these units also being found in S epsilon at a much lower density. S mu-S gamma 4 matches are infrequent, but S gamma 4 contains a cluster of repeated sequences similar to units in mouse gamma switch sites and unrelated to the S mu repeats, suggesting that S mu-S gamma homology is not important in mu-gamma switching. We examined our epsilon and gamma 4 sequences for features that could regulate production of 'sterile' transcripts preceding switch recombination. There is an Evolutionarily Conserved Sequence (ECS) upstream from the human and mouse S epsilon regions that overlaps and extends 5' to the start sites for human and mouse epsilon sterile transcripts. Similarly, an ECS upstream from S gamma 4 is homologous to a mouse sequence that overlaps and extends 5' to the start sites for mouse gamma 2b sterile transcripts. The epsilon and gamma 4 conserved segments contain potential Interferon Stimulable Response Elements (ISRE's) that are identical between human epsilon and gamma 4.

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Citations

Sep 1, 1993·Genes, Chromosomes & Cancer·P E CrossenM J Morrison
Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D K JinN Kobayashi
Jul 5, 2003·International Journal of Hematology·Takeshi NamikiYasuhiko Kaneko
Aug 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C SchiffM Fougereau
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Li HanKefei Yu
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S K ShapiraR S Geha
Mar 1, 1996·The Journal of Experimental Medicine·F MalisanH Martinez-Valdez
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Feb 11, 1993·Nucleic Acids Research·W DunnickC Gritzmacher
Nov 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ashwin KotnisQiang Pan-Hammarström
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Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·D Vercelli
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Nov 22, 1997·European Journal of Immunology·R MussmannL Du Pasquier

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