Sequencing and Combination of Systemic Therapy in Metastatic Renal Cell Carcinoma

European Urology Oncology
Guillermo de VelascoBernard Escudier

Abstract

Introduction of additional new agents targeting the vascular endothelial growth factor receptor (VEGFR) and immune checkpoint inhibitors (ICIs) has completely modified the systemic treatment of metastatic renal cell carcinoma (mRCC) during the last years. A comprehensive (nonsystematic) review to determine the suggested sequence or combinations for the systemic treatment of mRCC. PubMed and abstracts from main conferences up to December 2018 were reviewed to retrieve the current evidence for treatment of mRCC. Search terms included renal cell carcinoma, systemic therapy, targeted therapy (TT), and immunotherapy. Marked advances in the treatment of mRCC have been made with novel VEGFR tyrosine kinase inhibitors and multiple ICIs that have been included in the current treatment paradigm of mRCC. Remarkable advance has been made with the combination of double checkpoint blockade. The combination of ipilimumab and nivolumab compared with sunitinib has shown to increase the overall survival in the intermediate- and poor-risk patients based on the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model. Double checkpoint blockade with ipilimumab and nivolumab has reported overall survival benefit in IMDC interm...Continue Reading

Citations

Dec 22, 2019·Cancers·Lucía Carril-AjuriaGuillermo de Velasco
Sep 12, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea B ApoloAmir Mortazavi
Mar 28, 2020·Therapeutic Advances in Medical Oncology·Elie RassyLaurence Albiges
Apr 10, 2020·JCI Insight·Nirmish SinglaJames Brugarolas
Aug 9, 2020·Medical Oncology·Gianluca PeregoFausto Petrelli
Jan 31, 2021·International Journal of Clinical Oncology·Giuseppe RosielloPierre I Karakiewicz
Dec 15, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Shingo HatakeyamaChikara Ohyama
Oct 4, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L AlbigesB Escudier
Aug 16, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mike WenzelPierre I Karakiewicz
Aug 28, 2021·International Journal of Molecular Sciences·Maria Rosaria MuroniMaria Rosaria De Miglio
Sep 1, 2021·JCO Clinical Cancer Informatics·Kevin SheeAnobel Y Odisho

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