Sequencing and transcriptional analysis of the Streptococcus thermophilus histamine biosynthesis gene cluster: factors that affect differential hdcA expression.

Applied and Environmental Microbiology
Marina Calles-EnríquezMiguel A Alvarez

Abstract

Histamine, a toxic compound that is formed by the decarboxylation of histidine through the action of microbial decarboxylases, can accumulate in fermented food products. From a total of 69 Streptococcus thermophilus strains screened, two strains, CHCC1524 and CHCC6483, showed the capacity to produce histamine. The hdc clusters of S. thermophilus CHCC1524 and CHCC6483 were sequenced, and the factors that affect histamine biosynthesis and histidine-decarboxylating gene (hdcA) expression were studied. The hdc cluster began with the hdcA gene, was followed by a transporter (hdcP), and ended with the hdcB gene, which is of unknown function. The three genes were orientated in the same direction. The genetic organization of the hdc cluster showed a unique organization among the lactic acid bacterial group and resembled those of Staphylococcus and Clostridium species, thus indicating possible acquisition through a horizontal transfer mechanism. Transcriptional analysis of the hdc cluster revealed the existence of a polycistronic mRNA covering the three genes. The histidine-decarboxylating gene (hdcA) of S. thermophilus demonstrated maximum expression during the stationary growth phase, with high expression levels correlated with high h...Continue Reading

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Citations

Aug 2, 2011·Applied and Environmental Microbiology·Victor LaderoMiguel A Alvarez
Sep 1, 2014·International Journal of Food Microbiology·Giulia TabanelliFausto Gardini
May 28, 2011·International Journal of Food Microbiology·Masataka SatomiYutaka Yano
Jun 17, 2016·Scientific Reports·Jian ZhangJianjun Qiao
Jan 10, 2019·Foods·Federica BarbieriGiulia Tabanelli
Mar 7, 2018·Scientific Reports·Beatriz Del RioMiguel A Alvarez
Jan 7, 2011·Molecular Microbiology·Hein TripJuke S Lolkema
Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Petra JančováLeona Buňková
Jan 29, 2021·Comprehensive Reviews in Food Science and Food Safety·Marta MonienteLaura Botello-Morte

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