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Sequencing of 50 human exomes reveals adaptation to high altitude

Science

Jul 3, 2010

Xin YiJian Wang

Abstract

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, wh...read more

Mentioned in this Paper

Epas1 protein, mouse
Dioxygen
Genome
Acclimatization
ARNT gene
Response to Hypoxia
ARNT protein, human
Candidate Gene Identification
Human gene
Genomics
13
22
2
1211
4
Paper Details
References
  • References21
  • Citations543
123
  • References21
  • Citations543
12345...

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Sequencing of 50 human exomes reveals adaptation to high altitude

Science

Jul 3, 2010

Xin YiJian Wang

PMID: 20595611

DOI: 10.1126/science.1190371

Abstract

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, wh...read more

Mentioned in this Paper

Epas1 protein, mouse
Dioxygen
Genome
Acclimatization
ARNT gene
Response to Hypoxia
ARNT protein, human
Candidate Gene Identification
Human gene
Genomics
13
22
2
1211
4

Feeds With Similar Papers

Hypoxia

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Here is the latest research.

Science eTOC

Science Magazine is a peer-reviewed academic journal of the American Association for the Advancement of Science. Find the latest research from Science here.

Related Papers

Science

Genetic evidence for high-altitude adaptation in Tibet

ScienceMay 15, 2010
Tatum S SimonsonRiLi Ge
Proceedings of the National Academy of Sciences of the United States of America

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

Proceedings of the National Academy of Sciences of the United States of AmericaJune 11, 2010
Cynthia M BeallYong Tang Zheng
Paper Details
References
  • References21
  • Citations543
123
  • References21
  • Citations543
12345...

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