PMID: 11921278Mar 29, 2002Paper

Sequencing of intron 3 of HMGA2 uncovers the existence of a novel exon

Genes, Chromosomes & Cancer
Sven HaukeJ Bullerdiek

Abstract

Aberrations affecting the gene encoding the high mobility group protein HMGA2 (formerly HMGIC) have been found in a variety of human tumors, e.g., uterine leiomyomas, lipomas, and pulmonary chondroid hamartomas. These aberrations lead to fusion genes, transcriptional up-regulation, or aberrant transcripts of HMGA2. In the latter case, truncated transcripts consisting of exons 1 to 3 of HMGA2, encoding the three DNA-binding domains, and ectopic sequences derived from chromosome 12 are frequent. There are several lines of evidence indicating that the biological and tumorigenic features of truncated HMGA2 derivatives, i.e., those composed of the DNA-binding domains and a shortened acidic tail, clearly differ from those of the normal protein consisting of three DNA-binding domains and one large acidic tail. By sequencing the complete 112 kb third intron of HMGA2, we were able to detect several of the ectopic sequences, known as fused to HMGA2. Expression studies revealed co-expression of one of these transcripts with the normal transcript in tumors with 12q14-15 aberrations as well as in other tumors, and in normal tissues. Thus, this transcript (HMGA2b) is flanked by an alternative terminal exon of HMGA2. Due to the loss of the pa...Continue Reading

References

Jan 22, 1982·Nucleic Acids Research·S M Mount
Jun 6, 1995·Biochemical and Biophysical Research Communications·P RogallaJ Bullerdiek
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 3, 1998·Biochemical and Biophysical Research Communications·L V KottickalL Nagarajan
Jul 9, 1999·Genes, Chromosomes & Cancer·G J GattasC C Morton

❮ Previous
Next ❯

Citations

Mar 12, 2009·European Journal of Human Genetics : EJHG·Francesca MariAndrea Superti-Furga
Aug 2, 2011·European Journal of Endocrinology·Darya Gorbenko del BlancoAnita C S Hokken-Koelega
May 11, 2005·Biochimica Et Biophysica Acta·Sven HaukeJörn Bullerdiek
Mar 18, 2005·Cancer Genetics and Cytogenetics·Avery A Sandberg
Apr 14, 2005·Seminars in Cancer Biology·Göran Stenman
Nov 11, 2008·Cancer Genetics and Cytogenetics·Inga von AhsenJörn Bullerdiek
Jan 26, 2020·International Journal of Molecular Sciences·Riccardo SgarraAnd Guidalberto Manfioletti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.