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Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Genes and Immunity

Oct 24, 2014

C T WatsonF Breden

Abstract

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively ha...read more

Mentioned in this Paper

Immunoglobulin Activity
Segmental Duplications, Genomic
Pathogenic Organism
Hydatidiform Mole
Bacterial Artificial Chromosomes
Immunoglobulins
IGH gene
Immunoglobulin Light Chains
Sequencing
Genes, Immunoglobulin VH Germ Line
6
1
30
Paper Details
References
  • References65
  • Citations10
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  • References65
  • Citations10
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Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Genes and Immunity

Oct 24, 2014

C T WatsonF Breden

PMID: 25338678

DOI: 10.1038/gene.2014.56

Abstract

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively ha...read more

Mentioned in this Paper

Immunoglobulin Activity
Segmental Duplications, Genomic
Pathogenic Organism
Hydatidiform Mole
Bacterial Artificial Chromosomes
Immunoglobulins
IGH gene
Immunoglobulin Light Chains
Sequencing
Genes, Immunoglobulin VH Germ Line
6
1
30

Similar Papers Found In These Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Copy Number Variation

Copy number variation refers to alterations in the number of gene copies or DNA sequences. It can be a duplication, amplification, or a deletion event. Here is the latest research.

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Paper Details
References
  • References65
  • Citations10
12345...
  • References65
  • Citations10
1
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