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Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Genes and Immunity

Oct 23, 2014

Corey T. WatsonFelix Breden

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Abstract

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively ha...read more

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  • Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

    Genes and Immunity

    Oct 23, 2014

    Corey T. WatsonFelix Breden

    PMID: 25338678

    DOI: 10.1038/gene.2014.56

    Abstract

    Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively ha...read more

    6
    1
    30

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