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Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

bioRxiv

Jul 3, 2014

Corey T. WatsonFelix Breden

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Abstract

Germline variation at immunoglobulin gene (IG) loci is critical for pathogen-mediated immunity, but establishing complete reference sequences in these regions is problematic because of segmental duplications and somatically rearranged source DNA. We sequenced BAC clones from the essenti...read more

Mentioned in this Paper

BAT Loci
Proximal
Immunoglobulin G
Genome
Gene Duplication
Clone
Genetic Loci
Genes
SLC3A2 gene
Nucleic Acid Sequencing
8
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  • Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

    bioRxiv

    Jul 3, 2014

    Corey T. WatsonFelix Breden

    PMID: 990006866

    DOI: 10.1101/006866

    Abstract

    Germline variation at immunoglobulin gene (IG) loci is critical for pathogen-mediated immunity, but establishing complete reference sequences in these regions is problematic because of segmental duplications and somatically rearranged source DNA. We sequenced BAC clones from the essenti...read more

    Mentioned in this Paper

    BAT Loci
    Proximal
    Immunoglobulin G
    Genome
    Gene Duplication
    8

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