Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon

Neuroscience
C A MaggiV Zagorodnyuk

Abstract

The aim of this study was to resolve the temporal relationships of the triple excitation of the circular muscle of guinea-pig colon that occurs in response to activation of the intrinsic excitatory nerves by using atropine and tachykinin NK1 and NK2 receptor selective antagonists to define the relative contribution of the transmitters involved. In organ bath experiments, performed in the presence of blockers of inhibitory innervation, a train of electrical pulses at 5 Hz for 300 s produced a sustained contraction of the circular muscle of guinea-pig colon: the sequential addition of atropine (1 microM), of the tachykinin NK1 receptor antagonist, SR 140333 (0.3 microM) and of the tachykinin NK2 receptor antagonist, MEN 11420 (1 microM) produced a cumulative inhibitory effect and progressively delayed the onset of the contractile response to nerve stimulation. In the presence of peptidase inhibitors, atropine was less effective in inhibiting the contractile response for prolonged periods of stimulation: however, the pattern of inhibition of the evoked response produced by the sequential addition of blocker drugs was not substantially affected. The selective tachykinin NK3 receptor agonist, senktide, produced a concentration-depen...Continue Reading

References

Dec 1, 1990·British Journal of Pharmacology·C A MaggiA Meli
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Citations

Apr 29, 2000·Trends in Pharmacological Sciences·R PatacchiniP Holzer
Dec 17, 2002·Current Opinion in Pharmacology·Alessandro LecciCarlo Alberto Maggi
Mar 15, 2002·Neuroreport·Susan Jones, Johanna L Gutlerner
Apr 1, 2005·Neuromodulation : Journal of the International Neuromodulation Society·Cristian SevcencuThomas Sinkjaer
Apr 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Cristian Sevcencu
Dec 5, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eamonn J DicksonTerence K Smith
Mar 29, 2013·Autonomic Neuroscience : Basic & Clinical·Raj K Goyal, Arun Chaudhury
Mar 24, 2004·British Journal of Pharmacology·Alessandro LecciCarlo Alberto Maggi
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C Sevcencu
Jan 24, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Cristian SevcencuThomas Sinkjaer
Aug 16, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider, Lea E Langdon
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L OnoriM Tonini

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