Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: updated analysis of the observational GioTag study

Future Oncology
Maximilian J HochmairTanja Cufer

Abstract

Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. Trial registration number: NCT03370770.

Associated Clinical Trials

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Citations

Dec 5, 2019·Future Oncology·Rachel Jenkins, Louis Gautier
Sep 5, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Vera Hirsh, Jaspal Singh
Jun 23, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·R Donald HarveyPatrick Medina
Jan 7, 2021·Future Oncology·Louis Gautier
Jan 3, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Filippo de MarinisDariusz Kowalski
Jan 27, 2021·Pharmaceuticals·Mei Elsayed, Petros Christopoulos
Apr 9, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mariano ProvencioAtocha Romero
Jun 15, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Chung-Shien LeeNagashree Seetharamu
Jul 16, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khi Pin ChuaDaniel S W Tan

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Methods Mentioned

BETA
biopsy
PCR

Clinical Trials Mentioned

NCT03370770

Software Mentioned

GioTag

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