PMID: 41564Nov 1, 1979

Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver

British Journal of Cancer
K OgawaE Farber

Abstract

The organizational pattern of hepatocytes in hyperplastic nodules, probable precursors of hepatocellular carcinoma, was examined sequentially at different stages in the carcinogenic process, and compared with the patterns in hepatocellular carcinomas, in developing liver and in regnerating liver. Scanning as well as transmission electron microscopy, and histochemistry with light microscopy were used. The hepatocytes in the hyperplastic lesions were arranged in plates 2 or more cells thick and glands, in contrast to the one-cell-thick plates of hepatocytes in normal mature liver, and showed unusualy separation from eachother, with irregularly dilated bile canaliculi. The organizational pattern found in the hyperplastic lesions shared properties with developing liver in the perinatal period, regenerating liver following the peak of cell division, and some hepatocellular carcinomas. Unlike the normal, in which there is a highly predictable time scale for change, an apparent delay or interruption of maturation may be of importance in lesions that persist and ultimately evolve into hepatocullular carcinoma.

Citations

Dec 1, 1989·The Journal of Membrane Biology·B Boyer, J P Thiery
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·M MatsumotoT Fukumoto
Jan 1, 1986·Critical Reviews in Toxicology·T L GoldsworthyH C Pitot
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Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T TomoyoriT Onoé
Jan 1, 1981·Acta Pathologica Japonica·E Farber
Mar 11, 2000·Archives of Histology and Cytology·T TakeishiM Naito
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·L C Eriksson, G N Andersson
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances

Related Concepts

Diethylnitrosamine
Fetal Structures
Gamma-glutamyl transferase
Liver
Hepatoma, Novikoff
Liver Regeneration
Scanning Electron Microscopy
Condition, Preneoplastic
Rats, Inbred F344

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