PMID: 9535249Apr 16, 1998Paper

Sequential annual administration of purified fusion protein vaccine against respiratory syncytial virus in children with cystic fibrosis

The Pediatric Infectious Disease Journal
P A PiedraP W Hiatt

Abstract

We recently showed the clinical benefit of the PFP-2 vaccine for respiratory syncytial virus (RSV) for children with cystic fibrosis (CF). To determine the safety and immunogenicity of yearly sequential administration of the PFP-2 vaccine in CF children. Twenty-nine of the 34 CF children who participated in the previous study were enrolled in this open label vaccine study. All of the CF children ages 2.6 to 8.9 years received the PFP-2 vaccine, the PFP/PFP group received the PFP-2 vaccine in 1993 and 1994 and the saline/PFP group received the vaccine for the first time in 1994. At entry demographic data and measurements of lung function and nutrition were collected. Microneutralization test, enzyme-linked immunosorbent assay to F protein and Western blot assay were performed on plasma drawn before and 4 weeks after vaccination and at the end of the RSV season. During the study weekly telephone calls were made and acute respiratory illnesses were evaluated. Baseline measurements were similar between groups. Systemic and local vaccine reactions were mild and similar for both groups. A 4-fold or greater neutralizing antibody rise to RSV occurred in 4 of 14 (28.6%) and 9 of 14 (64.3%) in PFP/PFP and saline/PFP groups (P = 0.13), re...Continue Reading

References

Mar 1, 1979·The American Journal of Clinical Nutrition·P V HamillW M Moore
Jun 1, 1992·The Journal of Infectious Diseases·R D HarringtonJ D Meyers
Jan 1, 1992·The Journal of Infectious Diseases·C PohlJ Ledesma-Medina
Apr 1, 1991·The Journal of Infectious Diseases·C B HallK C Schnabel
Mar 1, 1990·American Journal of Diseases of Children·J R GroothuisB A Lauer
Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Jul 10, 1986·The New England Journal of Medicine·C B HallH J Cohen
Nov 1, 1981·The American Journal of Clinical Nutrition·A R Frisancho
Aug 1, 1995·The Journal of Infectious Diseases·A R FalseyR F Betts
Jan 1, 1995·Clinical Microbiology Reviews·V G HemmingG R Siber
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E WhimbeyB Baxter

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Citations

Dec 1, 1999·Reviews in Medical Virology·M Zambon
Dec 12, 2001·Primary Care·W P Glezen
Feb 26, 2004·Paediatric Respiratory Reviews·Robert C Welliver
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna P Durbin, Ruth A Karron
Aug 2, 2002·The Pediatric Infectious Disease Journal·Pedro A Piedra
Jan 20, 2004·The Pediatric Infectious Disease Journal·Fernando P Polack, Ruth A Karron
Oct 5, 2001·Clinical Microbiology Reviews·P H Dennehy
Jul 16, 2005·Expert Opinion on Biological Therapy·Martin Cranage, Geraldine Taylor
Nov 5, 1999·The Journal of Pediatrics·C G Prober, W M Sullender
Sep 1, 2012·European Journal of Microbiology & Immunology·H FrickmannA E Zautner
Sep 15, 1999·Lancet·E A Simoes
May 1, 2002·Minerva pediatrica·G A Rossi
Sep 26, 2006·Journal of Medical Virology·Ann R FalseyEdward E Walsh
Aug 24, 2013·Expert Review of Respiratory Medicine·Patricia A JorqueraRalph A Tripp
Oct 13, 2006·Current Opinion in Infectious Diseases·M FocaL Saiman
Aug 22, 2001·Revista do Hospital das Clínicas·L F Bricks
Sep 19, 2002·The Pediatric Infectious Disease Journal·Martin C J Kneyber, Jan L L Kimpen
Dec 1, 2003·Paediatrics & Child Health·Valérie Sales, Elaine El Wang

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