Sequential appearance of gamma/delta- and alpha/beta-bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes

European Journal of Immunology
S OhgaK Nomoto

Abstract

To search for a potential role of T cell antigen receptor (TcR) gamma/delta-bearing cells in host-defense against Listeria monocytogenes, we analyzed the sequential appearance of gamma/delta and alpha/beta T cell in the peritoneal exudate cells (PEC) during an i.p. infection with sublethal dose (2 X 10(3) of viable Listeria organisms in mice. The PEC on day 1 after the infection consisted of 48% macrophages and 50% lymphocytes, most of which were surface IgM+ (B) cells. The number of PEC increased to the maximal level by day 3. The PEC at this stage contained an appreciable number of CD3+ T cells in addition to a large number of macrophages. Of the CD3+ cells, the proportion of CD4- CD8- cells, most of which expressed no TcR alpha/beta, increased to the maximal level on day 3 after the infection. In correlation with an increased number of CD3+ CD4- CD8- TcR alpha/beta- cells, high level of TcR gamma/delta chain gene messages was detected in the nonadherent population of the PEC on this stage. On the other hand, the PEC on day 8 contained an increased number of CD4+ CD8- and CD4- CD8+ cells which expressed TcR alpha/beta chain on their surface. These results suggest that the gamma/delta T cells precede the alpha/beta T cells in ...Continue Reading

References

May 1, 1978·Journal of General Microbiology·M MitsuyamaS Shimotori
Jan 1, 1989·Advances in Immunology·B J Fowlkes, D M Pardoll
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C A SargentR D Campbell
May 26, 1989·Science·J L Strominger
Jun 1, 1989·Nature·D H Raulet
Jun 1, 1987·The Journal of Experimental Medicine·D M PardollR H Schwartz
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G StinglJ E Coligan
Jun 30, 1988·Nature·C A Janeway
Mar 1, 1988·Immunology Today·C A JanewayA Hayday
Mar 7, 1985·Nature·D H RauletS Tonegawa
Jul 10, 1986·Nature·M B BrennerM S Krangel
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel

❮ Previous
Next ❯

Citations

Jan 1, 1991·Springer Seminars in Immunopathology·P C DohertyS R Carding
Jan 1, 1991·Springer Seminars in Immunopathology·K Nomoto, Y Yoshikai
Jan 1, 1992·Immunologic Research·L Lefrançois
Dec 16, 2000·Springer Seminars in Immunopathology·D A FerrickB L Beaman
Aug 1, 1991·Current Opinion in Immunology·W K BornR L O'Brien
Aug 1, 1991·Current Opinion in Immunology·S H Kaufmann
Jul 1, 1997·Research in Immunology·P Matsiota-BernardA Bernemann
Feb 24, 1998·Clinical and Experimental Immunology·K OlofssonM L Hammarström
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ShimonkevitzB L Kotzin
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·S H Kaufmann
Oct 1, 1990·The Journal of Experimental Medicine·S R CardingP C Doherty
Sep 1, 1991·The Journal of Experimental Medicine·K UyemuraR L Modlin
Jan 1, 1992·The Journal of Experimental Medicine·K HiromatsuK Nomoto
Sep 1, 1993·The Journal of Experimental Medicine·M J Skeen, H K Ziegler
Mar 21, 1998·The Journal of Experimental Medicine·D F Tough, J Sprent
Jul 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B SerushagoR Bortolussi
Mar 29, 2001·Microbiology and Immunology·M A SalamE Hoshino
Jan 1, 1996·Annual Review of Immunology·Y H ChienM P Crowley
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Shiang ChungAlfred Ayala
Nov 1, 1993·Immunobiology·M E MielkeH Hahn
Apr 27, 2013·International Reviews of Immunology·Leonardo M R Ferreira
Jan 1, 1997·The Korean Journal of Internal Medicine·H B LeeD S Ahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.