PMID: 7527740Dec 1, 1994Paper

Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL lpr/lpr antibodies

Clinical and Experimental Immunology
Judith A JamesJ B Harley

Abstract

Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated with sera from nine Sm D-positive patients, six patients with other autoimmune serology, and five normal human sera. Lupus patient sera which are Sm precipitin-positive bind various combinations of five regions of the peptide. The major antigenic region, Epitope 5 (REAVA(GR)10GGPRR), is bound by eight of nine Sm precipitin-positive sera tested. This region of Sm D shows significant sequence homology with Epstein-Barr nuclear antigen-1. To determine the fine specificity of the murine Sm response, four unique Sm D MoAbs derived from MRL lpr/lpr mice and three adult anti-Sm-positive MRL lpr/lpr mouse sera have been analysed. Two of these monoclonals, KSm 4 and Y12, as well as the MRL lpr/lpr sera tested, show binding with Epitope 5. Another of these monoclonals, KSm 2, binds octapeptides 84-91, DVEPKVKSKKREAVAG, which corresponds to Epitope 4 of this study. Antibodies from SLE patients with autoimmune serology other ...Continue Reading

References

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Citations

Aug 31, 2002·Journal of Molecular Recognition : JMR·Carol S LutzJudith A James
May 20, 2005·Rheumatology·G Riemekasten, B H Hahn
Mar 23, 2006·Annual Review of Immunology·Imelda BalboniPaul J Utz
Feb 4, 2006·Autoimmunity·Brian D PooleJudith A James
Aug 10, 2006·Current Opinion in Rheumatology·Judith A JamesR Hal Scofield
Sep 1, 2007·Expert Review of Clinical Immunology·Minoru SatohWestley H Reeves
Apr 24, 1999·European Journal of Biochemistry·D BahiaM Bach-Elias
Nov 17, 1999·Scandinavian Journal of Immunology·M R ArbuckleJ A James
Oct 31, 1998·Immunological Reviews·J A James, J B Harley
Dec 31, 2005·Arthritis and Rheumatism·Micah T McClainJudith A James
Jan 23, 2018·Frontiers in Microbiology·Mario E Cruz-Muñoz, Ezequiel M Fuentes-Pananá
Jul 13, 2002·Arthritis and Rheumatism·Fanny Monneaux, Sylviane Muller
May 1, 1997·European Journal of Immunology·P SibilleA Avrameas
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Micah T McClainJudith A James
Apr 5, 1997·Annals of the New York Academy of Sciences·J A JamesJ B Harley
Jan 13, 2006·Current Opinion in Chemical Biology·William H Robinson
Aug 2, 2001·Biochemical and Biophysical Research Communications·K M KaufmanJ A James

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