Sequential catalysis for stereoselective synthesis of complex polyketides

Natural Product Reports
Daniel HerkommerDirk Menche

Abstract

This review presents recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides. These include a novel domino reaction, based on a combination of a nucleophilic addition and a Tsuji-Trost reaction, an innovative sequence relying on an oxidative diyne cyclization and regioselective opening, as well as sequential cross coupling strategies. The design and scope of these methods are discussed and applications in complex target syntheses presented.

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Citations

Jun 24, 2015·Chemical Communications : Chem Comm·Akira MatsumotoSeijiro Matsubara
Aug 4, 2016·Organic Letters·Sebastian ThiedeDirk Menche
Mar 17, 2017·Chemical Communications : Chem Comm·Hui YangWen-Hua Zheng
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Sebastian BretzkeDirk Menche
Jan 25, 2020·Organic & Biomolecular Chemistry·Céline SperandioAdrien Quintard
Jun 10, 2015·Molecular Diversity·Simpal KumariAakanksha Mishra
Mar 23, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Adrien Quintard
Jul 9, 2021·Frontiers in Pharmacology·Qianqian XuYonghui Zhang
Jun 30, 2019·Organic Letters·Hui Yang, Wen-Hua Zheng

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