PMID: 6027645Jul 1, 1967Paper

Sequential changes in classes of RNA during compensatory growth of the kidney

The Journal of Experimental Medicine
R A Malt, W I Miller

Abstract

The synthesis of nuclear precursors of rRNA and of cytoplasmic mRNA has been estimated in mouse kidneys following contralateral nephrectomy. 1. The production of nuclear rRNA parallels mitotic activity in the proximal tubule cells. Its peak is 2 days after nephrectomy; there may be a second peak at 8 days. 2. The production of mRNA is almost the reciprocal of rRNA production. It is least at 2 days and most at 4 days after nephrectomy. It may also decrease immediately after nephrectomy. 3. Growing kidney cells may build a store of ribosomes before they elaborate mRNA. The sequential relation between rRNA and mRNA synthesis raises the possibility that production of rRNA could regulate the production of mRNA and that the stimulus to compensatory hypertrophy might need to act only long enough to set into motion the machinery for making rRNA, either directly or as a consequence of exhausting mRNA.

References

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Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·S H Wilson, M B Hoagland
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Citations

Nov 1, 1973·In Vitro·M A Fingerhut, R M Nardone
Jun 26, 1969·The New England Journal of Medicine·R A Malt
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M WillemsR A Malt
Jun 1, 1968·The Journal of Cell Biology·G C Priestley, R A Malt
Jun 1, 1969·The Journal of Cell Biology·G C Priestley, R A Malt
Oct 1, 1975·Archives internationales de physiologie et de biochimie·F Grégoire
Oct 28, 1969·Journal of Molecular Biology·B E MadenJ E Darnell
May 21, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F ScheiffarthH W Baenkler
Sep 1, 1968·Bacteriological Reviews·J E Darnell

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