PMID: 2484236Nov 1, 1989Paper

Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt-deficient grass

Biological Trace Element Research
D A RiceE A Goodall

Abstract

Methylmalonic acid (MMA) concentrations are elevated in plasma as a result of vitamin B12 deficiency. This study reports the sequential changes in plasma MMA in lambs maintained on a cobalt-deficient pasture compared with supplemented controls. The results indicate that MMA is elevated in the early stages of deficiency, preceding the onset of loss of production and clinical signs of disease. It remains elevated as long as the lambs are unsupplemented with cobalt (Co). The most striking clinical sign was a loss of body condition as opposed to weight. The defect in the methylmalonyl CoA mutase is obviously an early defect in cobalt deficiency.

References

May 1, 1979·New Zealand Veterinary Journal·K R Millar, P P Lorentz
Jun 15, 1979·The Biochemical Journal·A R NeillR M Dawson
Jan 1, 1989·Journal of Inherited Metabolic Disease·L B BaileyD Rice
Nov 14, 1987·The Veterinary Record·D A RiceC H McMurray
Nov 1, 1986·American Journal of Clinical Pathology·E J NormanP Terrell
Dec 4, 1974·Journal of Chromatography·K R Millar, P P Lorentz
Nov 1, 1973·New Zealand Veterinary Journal·K G HoganF M Gibb
May 1, 1970·The Australian Journal of Experimental Biology and Medical Science·J M Gawthorne
Mar 1, 1970·The Australian Journal of Experimental Biology and Medical Science·J M Gawthorne
Sep 29, 1984·The Veterinary Record·M F McLoughlinS M Taylor
May 1, 1984·In Practice·A Russel
Mar 1, 1980·Journal of Clinical Pathology·D L MollinS M Lewis
Sep 1, 1981·The British Journal of Nutrition·W R DuncanG A Garton

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Citations

May 26, 2007·Reproduction, Fertility, and Development·Linda M MitchellCathy M Dwyer
Jul 21, 2005·New Zealand Veterinary Journal·N D Grace, G R Sinclair
Feb 23, 2012·New Zealand Veterinary Journal·N D Grace, S O Knowles
Jul 21, 2005·New Zealand Veterinary Journal·N D Grace, P R Wilson
Nov 1, 1989·The British Journal of Nutrition·F P O'HarteD A Rice

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