PMID: 952688Jun 1, 1976

Sequential changes in the fade of tetanic tension after the administration of tubocurarine in anaesthetized man

British Journal of Anaesthesia
N SugaiJ P Payne


Tetanic and single twitch contractions of the adductor pollicis muscle in anaesthetized man were measured continuously following the i.v. injection of tubocurarine 0.2 mg/kg. Tetanic contractions were depressed earlier by tubocurarine and to a greater extent compared with the single twitch. Recovery was also slower for the tetanic contractions. The fade of tetanic tension was also measured throughout the blockade produced by tubocurarine. Fade was expressed in terms of the tetanic tension ratio: the ratio of the magnitude of the muscle tension at the end of 1 s of tetanic contraction compared with its peak height at the beginning of that contraction. Tetanic tension was well maintained during the onset of the neuromuscular block but was less well maintained during the recovery phase. It is suggested that the assessment of tetanic tension fade shoudl be carried out throughout the various stages of curarization.


Jan 1, 1976·Canadian Anaesthetists' Society Journal·R HughesN Sugai
Sep 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J R KambamB V Sastry
Apr 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R J StorellaH Rosenberg
Nov 1, 1978·British Journal of Clinical Pharmacology·R Hughes, J P Payne
May 1, 1979·British Journal of Clinical Pharmacology·R Hughes, J P Payne
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·F A WaliE J McAteer
Nov 1, 1986·British Journal of Pharmacology·A J Gibb, I G Marshall
Dec 1, 1980·Acta Anaesthesiologica Scandinavica·T Tammisto, M Salmenperä

Related Concepts

Anesthesia, Intratracheal
Muscle Tonus
Tubocurarine Chloride

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.