PMID: 952688Jun 1, 1976

Sequential changes in the fade of tetanic tension after the administration of tubocurarine in anaesthetized man

British Journal of Anaesthesia
N SugaiJ P Payne

Abstract

Tetanic and single twitch contractions of the adductor pollicis muscle in anaesthetized man were measured continuously following the i.v. injection of tubocurarine 0.2 mg/kg. Tetanic contractions were depressed earlier by tubocurarine and to a greater extent compared with the single twitch. Recovery was also slower for the tetanic contractions. The fade of tetanic tension was also measured throughout the blockade produced by tubocurarine. Fade was expressed in terms of the tetanic tension ratio: the ratio of the magnitude of the muscle tension at the end of 1 s of tetanic contraction compared with its peak height at the beginning of that contraction. Tetanic tension was well maintained during the onset of the neuromuscular block but was less well maintained during the recovery phase. It is suggested that the assessment of tetanic tension fade shoudl be carried out throughout the various stages of curarization.

Citations

Jan 1, 1976·Canadian Anaesthetists' Society Journal·R HughesN Sugai
Sep 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J R KambamB V Sastry
Apr 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R J StorellaH Rosenberg
Nov 1, 1978·British Journal of Clinical Pharmacology·R Hughes, J P Payne
May 1, 1979·British Journal of Clinical Pharmacology·R Hughes, J P Payne
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·F A WaliE J McAteer
Nov 1, 1986·British Journal of Pharmacology·A J Gibb, I G Marshall
Dec 1, 1980·Acta Anaesthesiologica Scandinavica·T Tammisto, M Salmenperä

Related Concepts

Anesthesia, Intratracheal
Hemodynamics
Inotropism
Muscle Tonus
Muscle
Tubocurarine Chloride

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