Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis

Annals of the Rheumatic Diseases
E Gómez-BarrenaG Herrero-Beaumont

Abstract

To investigate immunolocalisation of parathyroid hormone related protein (PTHrP) in two sequential models of experimental cartilage damage (inflammatory and degenerative) in order to elucidate differences in chondrocyte response to the disease. Immunohistochemistry with a polyclonal rabbit antiserum to the N-terminal domain of PTHrP was used to detect this protein in two different rabbit models sharing progressive cartilage damage: antigen induced arthritis (AIA) and osteoarthritis (OA) secondary to partial medial meniscectomy. Cartilage specimens from early (2 days in AIA; 8 weeks in experimental OA) and late (3 weeks in AIA; 52 weeks in OA) disease were compared. Cell and matrix PTHrP staining in early AIA and OA was similar to that in controls. Late AIA cartilage showed a significant decrease in PTHrP positive cells and in the cartilage matrix. In contrast, at late OA stages, distinct PTHrP positivity was detected in proliferating cell clones, as assessed by proliferating cell nuclear antigen staining around cartilage damaged areas. PTHrP staining of hyaline articular cartilage shows a different pattern during progression of each type of arthritis: an overall decrease associated with the inflammatory disease, and an increase...Continue Reading

References

Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A van der SluijsJ Drukker
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H KohnoT Nakamura
Mar 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K OkanoS Yamashita
Jan 7, 1998·Arthritis and Rheumatism·O Sánchez-PernauteG Herrero-Beaumont
Jan 20, 2000·The New England Journal of Medicine·G J Strewler
Feb 29, 2000·Arthritis and Rheumatism·M J BenitoG Herrero-Beaumont
Dec 21, 2000·Current Rheumatology Reports·G A Karpouzas, R A Terkeltaub
Jul 27, 2001·Osteoarthritis and Cartilage·E CalvoG Herrero-Beaumont

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Citations

Apr 3, 2007·Rheumatology International·M Angeles Alvarez-SoriaGabriel Herrero-Beaumont
Dec 20, 2008·Journal de la Société de biologie·Marie-Thérèse CorvolFrançois Rannou
Aug 10, 2006·Current Opinion in Rheumatology·Laurent G Ameye, Marian F Young
Nov 30, 2013·Arthritis Research & Therapy·Jeroen C H LeijtenMarcel Karperien

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