Sequential changes of serum KL-6 predict the progression of interstitial lung disease

Journal of Thoracic Disease
Ying JiangRongchang Chen

Abstract

Interstitial lung disease (ILD) is a slowly progressing fatal fibrotic lung disease with a widely variable clinical course and a poor prognosis. Clinicians and patients would benefit from a highly efficient and accurate predictor for ILD. The purpose of this study was to evaluate whether blood biomarkers can predict ILD progression. In this study, 85 patients diagnosed as having ILD at the Guangzhou Institute of Respiratory Health participated, including 20 patients with idiopathic pulmonary fibrosis (IPF). During the mean follow-up time of 12 months, every patient was examined during four or five visits in our center. Serum samples were collected at baseline, and after 1, 2, 6, and 12 months and tested for the Klebs von den Lungen-6 (KL-6) concentration. Dynamic fluctuations in this biomarker concentration were examined using a logistic regression model to see if they reflected the progression of ILD. The baseline levels of serum KL-6 in the ILD patients were significantly increased compared to healthy controls. Serum KL-6 levels were significantly elevated in patients with progression of disease (1,985.2±1,497.8 vs. 1,387.6±1,313.1 µg/mL; P<0.001). Logistic regression revealed sequential changes of KL-6 was a significant pred...Continue Reading

Citations

Mar 16, 2019·Respiratory Research·Martin Kolb, Martina Vašáková
Sep 24, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Yuan JiCharles McSharry
Oct 23, 2020·Immunologic Research·Laura BergantiniElena Bargagli
May 17, 2021·Transplantation Reviews·Eline A van der PloegC Tji Gan
Jul 3, 2021·International Journal of Molecular Sciences·Anna StainerFabrizio Luppi

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