PMID: 6161273Aug 15, 1980Paper

Sequential combination chemotherapy with vinblastine/bleomycin and adriamycin/cis-dichlorodiammineplatinum (II) in non-seminomatous testicular cancer. I. Results of a prospective randomized phase III-study with 71 patients with disseminated disease (stage IV) (author's transl)

Klinische Wochenschrift
M E ScheulenC G Schmidt

Abstract

74 patients with disseminated non-seminomatous testicular cancer were randomly entered on a prospective sequential combination chemotherapy regimen with mandatory crossover, consisting of either vinblastine/bleomycin or adriamycin/cis-dichlorodiammineplatinum (II) (DDP) as initial therapy. Independent of the randomization the overall remission rate in 71 evaluable patients was 89% including 54% complete remissions. 35% of the patients remained disease-free at 2+ to 28+ months with a median of 12 months. By additional surgical removal of residual pulmonary metastases in two patients the complete remission rate was increased to 40/71 (56%), and the number of patients with no evidence of disease to 27/71 (38%). According to the life-table method the two-years survival rates were 63% for complete responders and 29% for all other patients, which was significantly lower. 53 patients (75%) were alive at 3 to 28 months with a median of 9 months. Additional advanced abdominal disease, initially elevated beta-HCG and LDH and extension of pulmonary disease were of significant negative influence on the prognosis. The evaluation of single chemotherapy courses revealed equal efficacy of both combinations. However, response to adriamycin/DDP ...Continue Reading

References

Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Feb 1, 1974·Annals of Internal Medicine·R H Blum, S K Carter
Aug 1, 1972·The Journal of Urology·S MonfardiniG Bonadonna
May 1, 1953·Cancer·F J DIXON, R A MOORE
Dec 1, 1958·Journal of Chronic Diseases·S J CUTLER, F EDERER
Nov 5, 1960·JAMA : the Journal of the American Medical Association·M C LIH GRABSTALD

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