Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187

Prostaglandins
C W ParkerM M Huber

Abstract

In rat basophilic leukemia (RBL-1) cells stimulated with A-23187, the major slow reacting substance (SRS) species contain glutathione, cysteinyl-glycine, or cysteine in their side chains, corresponding or closely related to leukotrienes LTC4, LTD4, and LTE4, respectively. Evidence is presented that most of the SRS produced during the first few minutes of stimulation by the ionophore has a glutathionyl side chain which is sequentially converted to cysteinyl-glycine and cysteine.

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Citations

Jun 1, 1996·In Vitro Cellular & Developmental Biology. Animal·N MatsuoM Sugano
Dec 16, 1980·Biochemical and Biophysical Research Communications·C W ParkerS F Falkenhein
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Apr 1, 1984·Journal of the American Academy of Dermatology·M E Goldyne
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Sep 1, 1982·The American Journal of Physiology·S R FindlayC R Scheid

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