Sequential delivery of BMP-2 and BMP-7 for bone regeneration using a heparinized collagen membrane

International Journal of Oral and Maxillofacial Surgery
J-Y JoJ-B Huh

Abstract

To investigate the effect of the sequential delivery of bone morphogenetic proteins BMP-2 and BMP-7 on bone regeneration in rat calvarial defects (40 Sprague-Dawley rats, 8mm defect size), all animals were treated with a hydroxyapatite (HA)/tricalcium phosphate (TCP) bone graft covered with a collagen membrane. The experimental groups were as follows: (1) control group: unmodified collagen (no treatment); (2) BMP-2 group: 5 μg of BMP-2; (3) hep-BMP-7 group: 5 μg BMP-7 chemically bound to heparinized collagen; and (4) BMP-2/hep-BMP-7 group: 2.5 μg BMP-7 bound to heparinized collagen and subsequently treated with 2.5 μg BMP-2. Defect healing was examined at 2 and 8 weeks after surgery. The BMP-2 group showed the largest new bone area at week 2 (29.3 ± 7.3%; P = 0.009); new bone areas in the hep-BMP-7 and BMP-2/hep-BMP-7 groups were similar (11.8 ± 3.4% and 12.9 ± 5.71%, respectively; P = 0.917). After 8 weeks, the BMP-2/hep-BMP-7 group showed the largest new bone area (43.3 ± 6.2%), followed by the BMP-2 and hep-BMP-7 groups (P = 0.013). Accordingly, in comparison with single deliveries of BMP-2 and BMP-7, sequential delivery of BMP-2 and BMP-7 using a heparinized collagen membrane significantly induced new bone formation with a ...Continue Reading

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Citations

Jul 18, 2015·International Journal of Molecular Sciences·Jung-Bo HuhSang-Wan Shin
Sep 7, 2016·BioMed Research International·Diana María Escobar-GarcíaAmaury Pozos-Guillén
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Howa BegamAbhijit Chanda
Apr 5, 2017·Tissue Engineering. Part B, Reviews·Chenyu ChuYi Man
Oct 5, 2017·Journal of Biomedical Materials Research. Part a·Beom Soo JoYoon Jeong Park
Jan 10, 2019·Journal of Clinical Periodontology·Nikos DonosElena Calciolari
Apr 13, 2018·Stem Cells and Development·Linyuan FanRobert Chunhua Zhao
Dec 2, 2017·Drug Delivery and Translational Research·Mathieu MaisaniOlivier Chassande
Aug 31, 2015·Materials·Zeeshan SheikhMichael Glogauer
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Chi-Chang Lin, Jiun-Yan Chiu
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Xuan ZhaoJin Yuan
May 4, 2021·Advanced Healthcare Materials·Yiting LouBinbin Ying
Aug 11, 2021·Pharmaceutics·Dragana Bjelić, Matjaž Finšgar
Nov 19, 2021·Frontiers in Cell and Developmental Biology·Yanping GongZhong-Kai Cui

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