Sequential dynamics of monocyte chemotactic protein-1 expression in herniated nucleus pulposus resorption

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
H HaroK Shinomiya

Abstract

We previously demonstrated that the granulation tissues of herniated nucleus pulposus are composed of a marked infiltration of macrophages that strongly express monocyte chemotactic protein-1. Monocyte chemotactic protein-1 is a chemotactic cytokine that contributes to the activation and recruitment of macrophages. Relatively little is known about its role in the resorption process of herniated nucleus pulposus. To clarify the sequential dynamics of expression of monocyte chemotactic protein-1 in the granulation tissues of herniated nucleus pulposus, we introduced a rat autologous transplantation model of nuclear materials onto its lumbar dura mater and performed immunohistological analysis and competitive polymerase chain reaction assay using the grafted samples. Immunohistological analysis demonstrated that the majority of infiltrating mononuclear cells expressed monocyte chemotactic protein-1. Monocyte chemotactic protein-1 mRNA was expressed in the first 3 weeks after the procedure and was significantly and maximally upregulated at 1 week. To determine whether human recombinant monocyte chemotactic protein-1 facilitates the resorption process of herniated nucleus pulposus, we introduced another model of autologous transplan...Continue Reading

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Citations

Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Masakazu YoshidaAkihiro Matsukawa
Jan 26, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·L GrangR Juvin
Apr 30, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hirotaka Haro
Dec 5, 2006·Journal of Manipulative and Physiological Therapeutics·Gregory CramerJoel Pickar
Sep 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Koji FujitaHirotaka Haro
Jun 21, 2005·Biomaterials·Sadahiro IwabuchiHirotaka Haro
Nov 14, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mitsufumi NakawakiMasashi Takaso
Dec 16, 2003·Spine·J G BurkeJ M Fitzpatrick
Nov 8, 2018·Arthritis Research & Therapy·Carla CunhaMário A Barbosa

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