PMID: 6411883Aug 1, 1983Paper

Sequential histological changes and mast cell response in skin during chemically-induced carcinogenesis

Journal of Oral Pathology
A Farnoush, I C Mackenzie

Abstract

Skin tumors experimentally induced by dimethylbenzanthracene (DMBA) are associated with dense subepithelial accumulations of mast cells. To investigate the sequential changes of the mast cell population during carcinogenesis, and to provide a model with which to examine mast cell proliferation, the back skin of 48 Swiss Webster mice was painted with 0.5% DMBA in benzene twice weekly for 12 weeks. Control and DMBA-treated tissues were processed for histological examination. The observed pattern of tissue changes fell into four phases: a) inflammation and necrosis followed by epithelial regeneration and hyperplasia, b) development of localized regions of acanthosis, c) loss of normal organization with downgrowth of epithelial cells and formation of keratin pearls, d) appearance of well-defined nodules resembling verrucous carcinoma. Subepithelial mast cells varied greatly in number during the above sequence of changes. Dense foci of cells were seen, particularly beneath the regions of hyperplastic epithelium. Mast cells may play a role in abnormal epithelial proliferation and, further, DMBA treatment may provide a suitable model with which to examine the origin and kinetics of mast cells.

References

Nov 1, 1975·Journal of Periodontal Research·A Farnoush, K Nuki
Sep 1, 1979·Histopathology·K Lennert, M R Parwaresch
Jun 1, 1978·Annals of Internal Medicine·D YooW N Jensen
Jul 30, 1976·Cell and Tissue Research·K NorrbyL Franzén
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P J Tutton
Feb 7, 1970·Nature·P R Burch
Feb 1, 1981·Journal of Oral Pathology·M E KreavichJ P Waterhouse
Mar 1, 1981·The Journal of Experimental Medicine·W R HendersonS J Klebanoff
Oct 1, 1980·Cellular Immunology·E Farram, D S Nelson
Jan 1, 1981·American Journal of Clinical Pathology·M Prokocimer, A Polliack
Jan 1, 1960·Zeitschrift für Zellforschung und Mikroskopische Anatomie. Abteilung Histochemie·G BLOOM, J W KELLY
Jan 20, 1962·Nature·L FIORE-DONATIL CHIECO-BIANCHI
Sep 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J PADAWER

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Citations

Apr 1, 1986·Clinical & Experimental Metastasis·M K DabbousG L Nicolson
Jan 1, 1986·Archives of Dermatological Research·T Tanaka, A Rivenson
Sep 12, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Michele GiulianiRoberta Ricci
Apr 4, 2007·Biochemical Pharmacology·Yuan-Soon HoYing-Jan Wang
Jan 1, 1985·Journal of Periodontal Research·A Farnoush, K Nuki
Aug 1, 1984·Journal of Oral Pathology·A Farnoush, I C Mackenzie
May 1, 1985·Journal of Oral Pathology·L V StonciusJ Meyer
Mar 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Margareta M Mueller
Nov 26, 2013·The Cancer Journal·Sabine Hensler, Margareta M Mueller
Dec 4, 2003·Journal of Clinical Laser Medicine & Surgery·Tapan K GayenR R Alfano
Aug 24, 1999·European Journal of Immunology·N KanbeH Matsuda
Apr 24, 2007·The Journal of Nutrition·Joshua S RussellPatricia A Masso-Welch
May 1, 1992·The Journal of Investigative Dermatology·N C KrejciJ McGuire

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