PMID: 3153057Oct 1, 1988

Sequential hypertonic haemodialysis in children

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M FischbachJ Geisert


Sequential hypertonic dialysis (SHD) was studied in two binephrectomized children over a period of 6 weeks. Each dialysis session comprised four periods of 45 min. The concentration of sodium in the dialysate [Na(D)] during the first period was 190 mmol/l and during the second period 140 mmol/l. The sequence was then repeated. The sodium-free water clearance [C(ONa)] was calculated from the measurements of the ultrafiltrate clearance and of the sodium clearance. Despite the short periods of hypertonic dialysis, C(ONa) was positive, suggesting that water was removed from the intracellular compartment as well as from the extracellular fluid. The transfer of fluid from the intracellular space improved circulatory stability during rapid removal of large volumes of fluid by ultrafiltration. SHD was also associated with increased removal of potassium and phosphate. Comparison of clinical parameters before and during SHD showed a tendency towards increased sodium balance and the possibility of raised cardiovascular morbidity. SHD stabilized blood volume during ultrafiltration, encouraging removal of uraemic toxins. SHD with this level of Na(D) is only a study dialysis method.


Jan 1, 1985·Nephron·A Martin-MaloP Aljama
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Jan 1, 1969·Scandinavian Journal of Urology and Nephrology·K E HagstamG Tibbling
Aug 1, 1969·Metabolism: Clinical and Experimental·W H Waugh
Jan 1, 1984·Nephron·F LocatelliC Pozzi
Jan 1, 1984·Nephron·J L Funck-Brentano, N K Man


Jun 11, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M FischbachEuropean Pediatric Dialysis Working Group
Jan 25, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Daljit HothiDenis F Geary
Apr 11, 2012·Seminars in Dialysis·Mark R Marshall, Joanna L Dunlop
Sep 4, 2015·Seminars in Dialysis·Carlo Basile, Carlo Lomonte
Mar 12, 2004·Nephrology·Moon-jae KimSeoung woo Lee
Nov 21, 2007·Hemodialysis International·Fernanda S MeiraAna E Figueiredo
Oct 27, 2001·Seminars in Dialysis·S StillerH Mann
Jul 31, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Werner KeenswijkMignon McCulloch
Jan 16, 2019·The Cochrane Database of Systematic Reviews·Joanna L DunlopMark R Marshall
Oct 19, 2019·BMC Nephrology·Damien AshbyMartin Wilkie

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