PMID: 7537593Feb 1, 1995Paper

Sequential induction of nitric oxide synthase by Corynebacterium parvum in different organs of the mouse

British Journal of Pharmacology
D D ReesS Moncada

Abstract

1. The ability of Corynebacterium parvum (C. parvum) to induce nitric oxide (NO) synthase in the macrophage, spleen, liver, aorta, heart and brain, and to elevate plasma NO2-/NO3- in the mouse was investigated. In addition, the relationship between NO synthase activity and blood pressure was studied. 2. C. parvum (100 mg kg-1, i.p.) induced a time-dependent expression of a Ca(2+)-independent NO synthase in the macrophage, spleen, liver, aorta and heart. The time course of induction of the NO synthase varied such that the maximum enzyme activity was at day 8 in the macrophage and liver, day 12 in the spleen and heart and day 16 in the aorta. 3. There was no significant induction of a Ca(2+)-independent NO synthase in the brain, nor was there any change in the Ca(2+)-dependent enzyme in this organ, during the study period. 4. C. parvum produced a gradual decrease in blood pressure, with a maximum fall at day 16 (from 108 +/- 1 mmHg to 79 +/- 3 mmHg), which recovered gradually by day 28. 5. Plasma NO2-/NO3- was significantly elevated between days 8 and 24, with a maximum increase at day 12. 6. These results show that C. parvum induces a Ca(2+)-independent NO synthase in a number of tissues and that this induction occurs initially ...Continue Reading

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Citations

Mar 25, 2004·The American Journal of Pathology·Rosa M E ArantesJoão S Silva
Aug 21, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·B GharibM De Reggi
Dec 13, 2000·Microbes and Infection·H TabelJ E Uzonna
Jul 1, 1998·British Journal of Pharmacology·D D ReesS Moncada
Jul 1, 1997·Archives of Disease in Childhood·C D GoonasekeraM J Dillon
Mar 1, 1996·Heart·K Bhagat, P Vallance
Sep 2, 2008·Cancer Research·S Perwez HussainCurtis C Harris
Feb 14, 2007·American Journal of Respiratory Cell and Molecular Biology·Michael Eisenhut
Dec 5, 2012·International Journal of Molecular Sciences·Sandro PercárioMichael D Green
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·S AmbsC C Harris
Jun 1, 1996·Clinics in Chest Medicine·D PayenS Beloucif
Aug 17, 2006·Shock·Yoram VodovotzGilles Clermont
Nov 10, 2006·The Plant Journal : for Cell and Molecular Biology·Maria Concetta de PintoLaura De Gara
Jun 6, 2000·British Journal of Cancer·M KorbelikD J Chaplin
Aug 13, 2004·The European Journal of Neuroscience·Carolina MunhozJuan C Leza
Aug 28, 2004·The American Journal of Gastroenterology·Luis MenchénPedro Lorenzo
Jul 1, 2005·Shock·Carson C ChowYoram Vodovotz
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José L M MadrigalJuan C Leza
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·K Bhagat, P Vallance
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S PfeifferB Mayer

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