Sequential intravenous allogeneic mesenchymal stromal cells as a potential treatment for thromboangiitis obliterans (Buerger's disease)

Stem Cell Research & Therapy
Jorge D Martin-RufinoFermin Sanchez-Guijo

Abstract

Thromboangiitis obliterans (TAO), also known as Buerger's Disease, is an occlusive vasculitis linked with high morbidity and amputation risk. To date, TAO is deemed incurable due to the lack of a definitive treatment. The immune system and inflammation are proposed to play a central role in TAO pathogenesis. Due to their immunomodulatory effects, mesenchymal stromal cells (MSCs) are the subject of intense research for the treatment of a wide range of immune-mediated diseases. Thus far, local intramuscular injections of autologous or allogeneic MSCs have shown promising results in TAO. However, sequential intravenous allogeneic MSC administration has not yet been explored, which we hypothesized could exert a systemic anti-inflammatory effect in the vasculature and modulate the immune response. Here, we report the first case of a TAO patient at amputation risk treated with four sequential intravenous infusions of bone marrow-derived allogeneic MSCs from a healthy donor. Following administration, there was significant regression of foot skin ulcers and improvements in rest pain, Walking Impairment Questionnaire scores, and quality of life. Sixteen months after the infusion, the patient had not required any further amputations. Thi...Continue Reading

References

Aug 9, 2001·Annals of Medicine·R Rabin, F de Charro
Sep 5, 2012·Clinical and Experimental Immunology·R Dellalibera-JovilianoP R B Evora
Mar 21, 2013·Annals of the New York Academy of Sciences·Siva S Ketha, Leslie T Cooper
Jun 22, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fermín Sánchez-GuijoJosé Antonio Pérez-Simon
Aug 26, 2014·VASA. Zeitschrift für Gefässkrankheiten·Peter F Klein-Weigel, Jutta G Richter
Oct 2, 2015·Cell Transplantation·Tiziana SquillaroUmberto Galderisi
May 5, 2016·Annals of Medicine and Surgery·Ignacio J Rivera-Chavarría, José D Brenes-Gutiérrez

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Methods Mentioned

BETA
amputation
density-gradient centrifugation
FACS
amputations

Software Mentioned

Infinicyt

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